During a 3 year period 48 patients with one or more blood cultures positive for Candida spp. were enrolled in the study. One patient presented 3 consecutives episodes of candidemia with infection of the port a cath. Fifty cases of candidemia were diagnosed. Candidemia with infection of the central venous catheter was the most frequent diagnosis (52%); in 20% of cases a tissue localization was also present (disseminated candidiasis). Thirty-four out of 50 episodes occurred in the Surgical Department. Among risk factors the most frequent resulted: prolonged antibiotic treatment (100%), intravascular catheter (86%), parenteral nutrition (74%), abdominal surgery (46%). C. albicans was identified more frequently than others Candida spp., resistance to fluconazole was detected in 20% of strains tested. 34/45 episodes of fungemia were treated with fluconazole, none reported side effects. In 5 cases fluconazole was discontinued for clinical failure. Clinical outcome in patients with Candida infection depends on other factors beside in vitro drug susceptibility tests.
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