Abdominal Aortic Aneurysms are a relatively common medical condition that occurs when the wall of the aorta expands to an above average diameter somewhere in the abdominal region of the body. Since an abdominal aortic aneurysm has a good chance of rupturing, which usually results in death, it must be detected and treated before rupture occurs. The current method of determining whether surgery is necessary depends on factors such as size and expansion rate of the aneurysm as well as the age and health of the patient. A proposed hypothesis is that the ratio of thrombus area to overall aneurysm area may also aid in determining whether surgery is necessary because it correlates to whether the aneurysm is stable or expanding. Currently the sizes of the aneurysm, thrombus and lumen are determined by manually measuring the diameter of the overall aneurysm and the diameter of the lumen, then employing these in the area formula for a circle to determine their respective sizes. The thrombus area is calculated by subtracting the area of the lumen from the area of the overall aneurysm. Since the aorta may not be perfectly circular in shape and this method is time consuming and error prone, an improved method for finding these areas is needed. This paper discusses a preliminary study of using MatLab as a tool to implement an algorithm that better approximates the area of the thrombus and overall aneurysm.
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Life Metab
February 2025
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China.
Abdominal aortic aneurysm (AAA) is strongly correlated with obesity, partially due to the abnormal expansion of abdominal perivascular adipose tissue (PVAT). Cell death-inducing DNA fragmentation factor-like effector C (CIDEC), also known as fat-specific protein 27 (FSP27) in rodents, is specifically expressed in adipose tissue where it mediates lipid droplet fusion and adipose tissue expansion. Whether and how CIDEC/FSP27 plays a role in AAA pathology remains elusive.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, P. R. China.
Int J Cardiovasc Imaging
January 2025
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
The use of conventional contrast agents in computed tomography (CT) and magnetic resonance (MR) imaging is often limited in patients with chronic kidney disease (CKD) due to potential nephrotoxicity. Ferumoxytol, originally developed for iron supplementation, has emerged as a promising alternative MR contrast agent that is safer for patients with CKD. This study aims to present our center's experience with ferumoxytol as a contrast agent in CKD patients.
View Article and Find Full Text PDFJ Vasc Surg Cases Innov Tech
April 2025
Division of Vascular and Endovascular Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
Adverse iliofemoral anatomy represents a unique challenge for endovascular aortic aneurysm repair (EVAR). This report describes a transaxillary EVAR in a patient with severe iliofemoral occlusive disease and an infrarenal aortic aneurysm. A reversely mounted Gore Excluder graft was advanced and deployed in the infrarenal aorta using the left axillary artery.
View Article and Find Full Text PDFRen Fail
December 2025
Department of Nephrology, Chengyang District People's Hospital, Qingdao, China.
Background: Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.
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