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Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy. | LitMetric

AI Article Synopsis

  • - The study compared 24 HIV-infected children with cardiac impairment to 24 HIV-infected controls, finding that all had evidence of coxsackievirus infection but no significant difference in antibody levels between the two groups.
  • - Statistical analysis using conditional logistic regression showed an odds ratio of 1.11, suggesting no link between coxsackievirus infection and cardiac issues in these children.
  • - Additional tests indicated that coxsackievirus antibody levels correlated with total IgG in some patients, but no new infections were detected after cardiac impairment diagnosis, pointing away from coxsackieviruses as a cause of heart problems in this population.

Article Abstract

In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P=.75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422982PMC
http://dx.doi.org/10.1086/340819DOI Listing

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