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Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized Wistar rats.
Curr Res Toxicol
November 2024
Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Background: Although menopause is a component of chronological aging, it may be induced by exposure to heavy metals like lead. Interestingly, lead exposure, just like the postmenopausal state, has been associated with spatial memory loss and neurodegeneration; however, the impact of hormone replacement therapy (HRT) on menopause and lead-induced spatial memory loss and neurodegeneration is yet to be reported.
Aim: The present study investigated the effect and associated mechanism of HRT on ovariectomized-driven menopausal state and lead exposure-induced spatial memory loss and neurodegeneration.
Hormone replacement therapy in surgical menopause after gynecological malignancies.
Biomol Biomed
November 2024
University of Novi Sad, Faculty of Medicine in Novi Sad, Novi Sad, Serbia; Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Vojvodina, Novi Sad, Serbia.
This review examines hormone replacement therapy (HRT) in cases of surgical menopause following gynecological malignancies. It aims to capture current knowledge, summarize recent findings, and provide recommendations for clinical settings. Unlike natural menopause, surgical menopause occurs abruptly, without an adjustment period, and is associated with a notably higher risk of fractures, arthritis, cognitive decline, dementia, Parkinson's disease, and various metabolic disorders affecting glucose and lipid levels-all of which contribute to an increased risk of major cardiovascular events.
View Article and Find Full Text PDFNovel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review.
Adv Pharm Bull
October 2024
Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Premature ovarian failure (POF), is a condition characterized by the early decline of ovulation function. POF is a complex disorder that can be caused by various factors, and the idiopathic form represents a significant proportion of POF patients. Hormone replacement therapy (HRT) is currently considered the first-line treatment for POF.
View Article and Find Full Text PDFHormone replacement therapy for menopausal mood swings and sleep quality: The current evidence.
World J Psychiatry
October 2024
Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.
Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women's health, leading to decreased well-being, psychological distress, and impaired quality of life. Common menopausal symptoms include hot flashes, sleep and mood changes, fatigue, weight gain, and urogenital disturbances. Clinicians often neglect mood swings and disrupted sleep, although those can significantly limit the productivity of women and impair their cognitive function and mental health.
View Article and Find Full Text PDFCommunity Empowerment and Mentality as a Treatment in Treatment-Resistant Trichotillomania: A Case Report.
Cureus
September 2024
Department of Psychiatry, Rowan-Virtua School of Osteopathic Medicine, Stratford, USA.
Trichotillomania, a psycho-dermatologic disorder defined by self-inflicted often noticeable hair loss through hair-pulling, is difficult to manage and treat. Its etiology is multifactorial and frequently is complicated by comorbid conditions like anxiety and depression. Evidence-based treatment is limited but options involve a combination of pharmacotherapy and cognitive-behavioral therapy (CBT), habit reversal training (HRT), and acceptance and commitment therapy (ACT).
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