The effect of AP and DMAA on the activity of Ro4-1284-induced PGO waves in lateral geniculate body (CGL) of cats is bidirectional. Higher doses decrease, whereas lower doses increase the intensity of PGO waves. DMAA inhibitis PGO activity in a dose-dependent manner. SP antagonizes AP inhibiting activity but does not affect the action of DMAA. The present study deals with the effect of AP and DMAA, the compounds stimulating central dopamine receptors, on the function of serotonin neurons.
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Brain Sci
September 2023
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Departments of Neuroscience, Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
Rapid eye movement (REM) sleep is the main sleep correlate of dreaming. Ponto-geniculo-occipital (PGO) waves are a signature of REM sleep. They represent the physiological mechanism of REM sleep that specifically limits the processing of external information.
View Article and Find Full Text PDFSleep
September 2023
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Ponto-geniculo-occipital or pontine (P) waves have long been recognized as an electrophysiological signature of rapid eye movement (REM) sleep. However, P-waves can be observed not just during REM sleep, but also during non-REM (NREM) sleep. Recent studies have uncovered that P-waves are functionally coupled with hippocampal sharp wave ripples (SWRs) during NREM sleep.
View Article and Find Full Text PDFNeurosci Res
April 2023
Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan; Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, Japan. Electronic address:
Dreams are mental experiences, including perceptions, thoughts, and emotions, that occur during sleep. In dreams, hallucinatory perceptions, particularly visual and motoric, are often accompanied by negative emotions. When people dream, they perceive them as real even though they are bizarre and distorted in time and space.
View Article and Find Full Text PDFCurr Res Physiol
February 2022
Lab. for Human Brain Dynamics, AAI Scientific Cultural Services Ltd., Nicosia, 1065, Cyprus.
High amplitude electroencephalogram (EEG) events, like unitary K-complex (KC), are used to partition sleep into stages and hence define the hypnogram, a key instrument of sleep medicine. Throughout sleep the heart rate (HR) changes, often as a steady HR increase leading to a peak, what is known as a heart rate surge (HRS). The hypnogram is often unavailable when most needed, when sleep is disturbed and the graphoelements lose their identity.
View Article and Find Full Text PDFNature
January 2021
Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep. These changes require precise homeostatic control by subcortical neuromodulatory structures. The underlying mechanisms of this phenomenon, however, remain unknown.
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