AI Article Synopsis
- The study analyzes mucosal tissues from 19 patients with oral lichen planus (OLP) and 10 healthy controls, focusing on changes in cell behavior such as proliferation and apoptosis.
- Elevated levels of markers like Ki-67 and cyclin D1 were found in OLP patients, indicating increased cell proliferation in the affected areas.
- The findings suggest that these cellular changes play a role in the unique tissue characteristics associated with OLP.
Article Abstract
Background: In oral lichen planus (OLP), destruction of the basal cell layer, which is one of the characteristic histological features, is seen and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium.
Methods: We studied mucosal tissues from 19 patients of OLP and 10 controls, with immunohistochemistry for Ki-67, p53, cyclin dependent kinase inhibitors (CDKI) and cyclins. Mitotic count was calculated. TUNEL assay was also performed for evaluation of apoptotic cell death.
Results: Mitotic count, Ki-67 and cyclin D1 labeling indices in the basal and parabasal layers of OLP mucosa were elevated in comparison with those of controls. p53, p21Cip1 and TUNEL indices of OLP mucosa were also increased.
Conclusions: These complex changes, which concomitantly occur in the injured mucosal epithelium, could contribute to the development and maintenance of characteristic mucosal epithelial architectures seen in OLP.
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| http://dx.doi.org/10.1034/j.1600-0714.2002.310403.x | DOI Listing |
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