Purpose: The purpose was to report a case of fungal keratitis that occurred following viscocanalostomy.
Methods: A 63-year-old man who underwent viscocanalostomy in his left eye presented with pain, redness, watering, and a decrease in visual acuity. Slit lamp examination showed teardrop-like stromal infiltration of the superior cornea. Corneal and conjunctival scrapings were obtained and a corneal biopsy was performed.
Results: Microscopic examination of smears demonstrated no bacteria and fungi. Corneal biopsy revealed dichotomously branching, septate hyphae suggestive of Aspergillus species. Culture identified no microorganism. The patient responded to amphotericin B treatment and the corneal infiltration resolved, leaving a plaquelike corneal scar.
Conclusion: Fungal keratitis may occur after viscocanalostomy, but prompt diagnosis and treatment can preserve the eye.
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http://dx.doi.org/10.1097/00003226-200207000-00019 | DOI Listing |
Ophthalmol Sci
November 2024
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Purpose: The diagnosis of fungal keratitis using potassium hydroxide (KOH) smears of corneal scrapings enables initiation of the correct antimicrobial therapy at the point-of-care but requires time-consuming manual examination and expertise. This study evaluates the efficacy of a deep learning framework, dual stream multiple instance learning (DSMIL), in automating the analysis of whole slide imaging (WSI) of KOH smears for rapid and accurate detection of fungal infections.
Design: Retrospective observational study.
Med Mycol Case Rep
March 2025
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
A 42-year-old woman was referred to an emergency department. She had an unresponsive corneal ulcer that was initially diagnosed as virus keratitis. Later, the microbiological studies revealed fungal keratitis.
View Article and Find Full Text PDFCornea
January 2025
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: To describe a case series of patients with 12 fungal keratitis treated with caspofungin 0.5% eye drops.
Methods: In this study, 12 patients diagnosed with fungal keratitis were treated with topical compounded caspofungin 0.
Invest Ophthalmol Vis Sci
January 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Purpose: Fungal keratitis (FK) remains a treatment challenge, necessitating new therapeutic targets. Piezo1, a mechanosensitive ion channel, regulates calcium signaling and immune cell function. This study investigates its role in macrophage-mediated antifungal responses in FK.
View Article and Find Full Text PDFClin Ophthalmol
January 2025
Center of Excellence for Cornea and Stem Cell Transplantation, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Purpose: To develop a comprehensively deep learning algorithm to differentiate between bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal corneas.
Methods: This retrospective study collected slit-lamp photos of patients with bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal cornea. Causative organisms of infectious keratitis were identified by either positive culture or clinical response to single treatment.
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