Since its discovery 2 decades ago, potent effects of corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress.
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| http://dx.doi.org/10.1016/s1050-1738(02)00157-3 | DOI Listing |
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