We delve into the study of a Markov chain formalism applied to the thermal prebiotic oligomerization of amino acids. We find for the case of only two types of electromagnetic interactions, that the steady state attainment by the Markov chain is a built in mechanism limiting the expected variability in sequences in a population of polymers. Such result may be of importance as it makes more accessible the replication of a minimal chemical machinery compatible with life.
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http://dx.doi.org/10.1016/s0303-2647(02)00008-4 | DOI Listing |
Heliyon
January 2025
Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Yunnan University, Kunming, 650500, China.
Global population growth and uncontrolled are creating threats to agricultural land. To address urbanization, proactive planning is required. Land use and land cover (LULC) classification maps for 2002-2022 were analyzed using remote sensing (RS) and geographic information systems (GIS) in Sahiwal, Punjab, Pakistan.
View Article and Find Full Text PDFCogn Neurodyn
December 2025
The Medical Big Data Research Center, Northwest University, Xi'an, 710127 China.
Insomnia, as a common sleep disorder, is the most common complaints in medical practice affecting a large proportion of the population on a situational, recurrent or chronic basis. It has been demonstrated that, during wakefulness, patients with insomnia exhibit increased EEG power in theta, beta, and gamma band. However, the relevant mechanisms underlying such power changes are still lack of understanding.
View Article and Find Full Text PDFBMJ Open
January 2025
Institute of Health Economics and Clinical Epidemiology, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany
Background: Magnetic resonance-guided transurethral ultrasound ablation (MR-TULSA) is a new focal therapy for treating localised prostate cancer that is associated with fewer adverse effects (AEs) compared with established treatments. To support large-scale clinical implementation, information about cost-effectiveness is required.
Objective: To evaluate the cost-utility of MR-TULSA compared with robot-assisted radical prostatectomy (RARP), external beam radiation therapy (EBRT) and active surveillance (AS) for patients with low- to favourable intermediate-risk localised prostate cancer.
J Dairy Sci
January 2025
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom. Electronic address:
This study investigated the genetics of bovine tuberculosis (bTB) infectivity in Holstein-Friesian dairy cows using British national data. The analyses included cows with recorded sires from herds affected by bTB outbreaks between 2000 and 2022. Animals were considered bTB-positive if they reacted positively to the skin test and/or had positive post-mortem findings.
View Article and Find Full Text PDFInt J Surg
December 2024
The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Background: This study aims to assess the comparative effectiveness and safety of robotic-assisted surgery (RAS), laparoscopy (LPS), and laparotomy (LPT) in improving perioperative indicators, lymph node dissection, and tumor survival outcomes in patients with Endometrial carcinoma (EC) through a systematic review and network meta-analysis.
Materials And Methods: We searched China National Knowledge Infrastructure, Wanfang, WeiPu, China Biology Medicine Disc, Embase, PubMed, Web of Science, and the Cochrane Library for randomized controlled trials (RCTs) and Cohort studies (CSs) involving RAS, LPS and LPT in individuals with EC. The network meta-analysis employed a Bayesian framework to integrate direct and indirect evidence, calculating Odds Ratios (OR) and Mean Difference (MD).
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