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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish.
Sci Rep
January 2025
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA.
Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant public health problem that will worsen with a warming climate and increased large-scale wildfires. Here, we characterize an epigenetic memory at the cytochrome P450 1 A (CYP1A) gene in wild Fundulus heteroclitus that have adapted to chronic, extreme PAH pollution. In wild-type fish, CYP1A is highly induced by PAH.
View Article and Find Full Text PDFReducing Cofilin dosage makes embryos resilient to heat stress.
bioRxiv
January 2025
Department of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
In addition to regulating the actin cytoskeleton, Cofilin also senses and responds to environmental stress. Cofilin can promote cell survival or death depending on context. Yet, many aspects of Cofilin's role in survival need clarification.
View Article and Find Full Text PDFComparative lipid profiling reveals the differential response of distinct lipid subclasses in blast and blunt-induced mild traumatic brain injury.
Exp Neurol
January 2025
Traumatic Brain Injury & Metabolomics Department, DRDO, Institute of Nuclear Medicine and Allied Sciences (INMAS), S. K Mazumdar Road, Timarpur, New Delhi 110054, India. Electronic address:
Head trauma from blast exposure is a growing health concern, particularly among active military personnel, and is considered the signature injury of the Gulf War. However, it remains elusive whether fundamental differences exist between blast-related Traumatic Brain Injuries (TBI) and TBI due to other mechanisms. Considering the importance of lipid metabolism associated with neuronal membrane integrity and its compromise during TBI, we sought to find changes in lipidomic profiling during blast or blunt (Stereotaxically Controlled Contusison-SCC)-mediated TBI.
View Article and Find Full Text PDFComparison of hemodynamic responses to nasal intubation in cancer patients receiving opioid-free general anesthesia versus standard regimen.
J Anaesthesiol Clin Pharmacol
November 2024
Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Background And Aims: Nasotracheal intubation evokes greater hemodynamic responses than oral intubation. We compared the heart rate (HR) and mean arterial pressure (MAP) responses following nasal intubation during opioid-free anesthesia (OFA) using intravenous lignocaine versus standard regimen using morphine in cancer patients undergoing tumor resection.
Material And Methods: This randomized, double-blinded study was conducted in 84 adults.
Protective Effects of Spondias mombin L. Juice Alone or in Combination With Lactobacillus acidophilus in 5-Fluorouracil-Induced Experimental Intestinal Mucositis.
Neurogastroenterol Motil
December 2024
Postgraduate Program in Oral Sciences, Postgraduate Program in Pharmaceutical Sciences, Department of Biophysical and Pharmacology, Federal University of Rio Grande Norte, Natal, Brazil.
Background: Evaluate the impact of Spondias mombin L. juice (SM), alone and in combination with Lactobacillus acidophilus, in an experimental model of intestinal mucositis.
Methods: Swiss mice were orally administered with saline, SM, or SM combined with L.
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