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Kety-Schmidt Application of Nitrous Oxide to Determine Cerebral Blood Flow.
J Anesth Hist
June 2020
Boston Medical Library, 10 Shattuck Street, Boston, MA 02115.
Article Synopsis
- - In the 1940s, researchers Seymour S. Kety and Carl F. Schmidt used nitrous oxide to measure blood flow in the brains of awake humans, which avoided the need for injections.
- - Nitrous oxide was chosen because it easily passed through the blood-brain barrier, did not interfere with metabolism, and was simple to detect.
- - Kety's work on this technique later helped lead to advancements in brain scanning technologies.
Human hypertension, sympathetic activity and the selfish brain.
Exp Physiol
December 2016
School of Physiology, Pharmacology and Neuroscience, Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.
What is the topic of this review? This review article revisits an historical hypothesis that cerebral hypoperfusion, caused by elevated cerebral vascular resistances, causes the onset of high sympathetic nerve activity and hypertension in humans. What advances does it highlight? The review article highlights new evidence indicating that congenital cerebrovascular abnormalities, namely vertebral artery hypoplasia and an incomplete posterior circle of Willis, may play a role in the onset of hypertension. Despite the harmful consequences of high blood pressure (hypertension; e.
View Article and Find Full Text PDFHistory of the Concept of Disconnectivity in Schizophrenia.
Harv Rev Psychiatry
October 2016
From Harvard Medical School and McLean Hospital, Belmont, MA.
Nearly 60 years ago Seymour Kety proposed that research on genetics and brain pathology, but not on neurochemistry, would ultimately lead to an understanding of the pathophysiology of schizophrenia. This article will demonstrate the prescience of Kety's proposal; advances in our knowledge of brain structure and genetics have shaped our current understanding of the pathophysiology of schizophrenia. Brain-imaging techniques have shown that schizophrenia is associated with cortical atrophy and ventricular enlargement, which progresses for at least a decade after the onset of psychotic symptoms.
View Article and Find Full Text PDFThe history of cerebral PET scanning: from physiology to cutting-edge technology.
Neurology
March 2013
Department of Neurology, Center for Movement Disorders & Neurorestoration, University of Florida College of Medicine, Gainesville, FL, USA.
Objective: To review the discoveries underpinning the introduction of cerebral PET scanning and highlight its modern applications.
Background: Important discoveries in neurophysiology, brain metabolism, and radiotracer development in the post-World War II period provided the necessary infrastructure for the first cerebral PET scan.
Methods: A complete review of the literature was undertaken to search for primary and secondary sources on the history of PET imaging.
[The landmarks of the measurement of cerebral blood flow].
Ideggyogy Sz
January 2008
Altalános Orvostudományi Kar, Idegsebészeti Tanszék, Budapest.
History of the measurement of local cerebral blood flow may cover a period of one and a half centuries. Parallel forthcoming of both theoretical and technical development were the key elements of ensuing progress resulting in the present state, when by the aid of in vivo blood flow and metabolic maps, we can visualize locales of brain functioning and their interconnections. Two theoretical landmarks should be mentioned in this historic process.
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