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| http://dx.doi.org/10.1104/pp.011021 | DOI Listing |
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How SNARE proteins generate force to fuse membranes.
Biophys J
January 2025
Department of Chemical Engineering, Columbia University, New York, NY 10027. Electronic address:
Membrane fusion is central to fundamental cellular processes such as exocytosis, when an intracellular machinery fuses membrane-enclosed vesicles to the plasma membrane for contents release. The core machinery components are the SNARE proteins. SNARE complexation pulls the membranes together, but the fusion mechanism remains unclear.
View Article and Find Full Text PDFSynergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and biological verification.
BMC Complement Med Ther
January 2025
Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
Background: Oral squamous cell carcinoma (OSCC) ranks as the sixth most common malignancy globally. Cisplatin is the standard chemotherapy for OSCC, but resistance often reduces its efficacy, necessitating new treatments with fewer side effects. Rumex dentatus L.
View Article and Find Full Text PDFRotating Hinge Revision Total Knee Arthroplasty With and Without Porous Cone Adjunct Fixation.
J Arthroplasty
January 2025
Georgetown University School of Medicine, MedStar Georgetown University Hospital, Washington, D.C, USA. Electronic address:
Introduction: As the number of revision total knee arthroplasties (rTKA) continues to rise, there is increasing interest in the use of contemporary rotating hinge prostheses. These devices often incorporate porous cones to fill bone defects and enhance long-term fixation. This study evaluated the clinical and functional outcomes and survivorship in rTKA patients utilizing a rotating hinge prosthesis with flexible titanium (FT) cones, porous tantalum (PT) cones, or no cones.
View Article and Find Full Text PDFHealth effects of occupational exposure to jet fuels used in the military: A systematic review of the epidemiologic literature.
Environ Int
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ICF, Reston, VA, USA. Electronic address:
Background: Jet fuels are a common chemical exposure in occupational settings involving aircraft. Jet fuels are heterogeneous mixtures of aromatic and aliphatic hydrocarbons, as well as non-hydrocarbon performance additives. Several components of jet fuels have been linked to adverse health outcomes.
View Article and Find Full Text PDFPrototype of AI-powered assistance system for digitalisation of manual waste sorting.
Waste Manag
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Chair of Waste Processing Technology and Waste Management, Montanuniversitaet Leoben, Leoben, Austria. Electronic address:
Global waste generation is projected to reach 3.40 billion tons by 2050, necessitating improved waste sorting for effective recycling and progress toward a circular economy. Achieving this transformation requires higher sorting intensity through intensified processes, increased efficiency, and enhanced yield.
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