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A case of Vibrio pelagius in a child with inflammatory bowel disease.
Indian J Med Microbiol
December 2024
Department of Microbiology, JIPMER, Puducherry, India. Electronic address:
We describe a rare case of an eleven-year-old child with undiagnosed underlying Crohn's disease who contracted Vibrio pelagius. Though the exact source remained undetermined, the child may have acquired it through infected sea food. Automated system failed to exactly identify the isolated organism; we used detailed biochemical tests for identification.
View Article and Find Full Text PDFStenotrophomonas maltophilia in Hemodialysis: An Opportunistic Pathogen or a Malevolent Foe.
Cureus
November 2024
Nephrology, SRM Medical College Hospital and Research Centre, Chennai, IND.
Catheter-related bloodstream infections (CRBSIs) add to the morbidity and mortality of hemodialysis patients. is an extremely resistant, gram-negative, non-lactose-fermenting nosocomial bacterium that contributes significantly to mortality and morbidity. This bacterium is predominantly associated with community-acquired pneumonia, bacteremia, eye afflictions, biliary sepsis, urinary tract infection, skin and soft tissue infection, and very rarely chronic enteritis with colonic ulcers.
View Article and Find Full Text PDFDevelopment of a dry powder formulation for pulmonary delivery of azithromycin-loaded nanoparticles.
J Pharm Pharm Sci
October 2024
Department of Biochemical and Pharmaceutical Technology, University of São Paulo, São Paulo, Brazil.
Article Synopsis
- The study focuses on developing a non-invasive inhalation method using polycaprolactone nanoparticles to deliver azithromycin for treating respiratory diseases like COVID-19 and pneumonia.
- The nanoparticles were created via an emulsion technique, producing a fine powder formulation that shows high encapsulation efficiency and favorable size for pulmonary delivery.
- Testing revealed the formulation maintains azithromycin’s antimicrobial effectiveness without causing cytotoxicity to human lung cells, indicating potential for improved treatment of lung infections.
Severe co-infection caused by difficult-to-diagnose hypermucoviscous Klebsiella pneumoniae K1-ST82 in a patient with COVID-19: a case report.
BMC Infect Dis
October 2024
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Background: Co-infection with Klebsiella pneumoniae presents a significant concern in hospitalized patients with coronavirus disease (COVID-19), increasing the risk of severe disease progression. Hypervirulent (hv) and hypermucoviscous (hm) K. pneumoniae (Kp) has gained prominence in Asia due to its capacity to cause invasive community-acquired infections.
View Article and Find Full Text PDFGenetic aspects of lactase deficiency in indigenous populations of Siberia.
Vavilovskii Zhurnal Genet Selektsii
October 2024
Institute of Biological Problems of the North of the Far Eastern Branch of the Russian Academy of Sciences, Magadan, Russia.
The ability to metabolize lactose in adulthood is associated with the persistence of lactase enzyme activity. In European populations, lactase persistence is determined mainly by the presence of the rs4988235-T variant in the MCM6 gene, which increases the expression of the LCT gene, encoding lactase. The highest rates of lactase persistence are characteristic of Europeans, and the lowest rates are found in East Asian populations.
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