A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models.

Bioorg Med Chem Lett

Dipartimento di Chimica Organica Ugo Schiff, Università degli Studi di Firenze, Polo Scientifico, I-50019 Sesto Fiorentino (FI), Italy.

Published: July 2002

The new fluorescent lipophilic moiety 11-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)amino]undecanoic acid (AMCA-omegaAud-OH) was introduced by SPPS at the N-terminus of the immunodominant epitope GpMBP(74-85). FRET experiments using the new fluorescent lipopeptide demonstrate that the peptide interacts with much more affinity with the membrane compared to the lipid free analogue.

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http://dx.doi.org/10.1016/s0960-894x(02)00253-6DOI Listing

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