We compared the results of Swan-Ganz measurements in 11 preeclamptic women and report of the hemodynamic profile in severe preeclampsia. Measurements were performed between 28-36 weeks of gestation.
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Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.
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December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
View Article and Find Full Text PDFFirst-Trimester Soluble sFlt-1 for the Prediction of Preterm Preeclampsia.
J Obstet Gynaecol Can
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Quebec City, Canada; Centre de recherche du CHU de Québec - Université Laval, Quebec City, Canada. Electronic address:
While soluble fms-like tyrosine kinase 1 (sFlt-1) is used to predict preeclampsia (PE) and its severity in late pregnancy, we aimed to clarify its role in early pregnancy. Using prospective cohorts, we estimated the association between sFlt-1, adjusted for gestational age, and preterm PE. sFlt-1 was significantly decreased in the first trimester, mostly before the 13th week, and significantly increased in the third trimester in those who developed preterm PE and particularly early-onset PE.
View Article and Find Full Text PDFProfilin-1 levels in preeclampsia: Associations with disease and adverse neonatal outcomes.
Placenta
December 2024
Department of Obstetrics and Gynecology, Ankara Etlik Zubeyde Hanim Women's Health Education and Research Hospital, Ankara, Turkey.
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View Article and Find Full Text PDFSpontaneous Hepatic Rupture Complicating Preeclampsia and HELLP Syndrome: A Case Report.
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Department of Surgery, Jimma Medical Center, Jimma University, Jimma, Ethiopia.
Spontaneous hepatic rupture is a rare complication that occurs in pregnant mothers with HELLP syndrome, or preeclampsia with severe features, or eclampsia. The most common symptom of hepatic rupture/hematoma is right upper quadrant pain or epigastric pain, which is similar to the presentation of preeclampsia with severe features. Therefore, the absence of specific signs and symptoms leads to a diagnostic dilemma and a delay in management.
View Article and Find Full Text PDFUtilizing machine learning to predict the risk factors of episiotomy in parturient women.
AJOG Glob Rep
February 2025
Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran (all authors).
Background: Episiotomy has specific indications that, if properly followed, can effectively prevent women from experiencing severe lacerations that may result in significant complications like anal incontinence. However, the risk factors related to episiotomy has been the center of much debate in the medical field in the past few years.
Objective: The present study used a machine learning model to predict the factors that put women at the risk of having episiotomy using intrapartum data.
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