AI Article Synopsis
- A study of 144 pulmonary tuberculosis patients found that serum adenosine deaminase (ADA) levels were significantly higher than in healthy individuals, with activity increasing according to disease severity.
- In caseous pneumonia, ADA levels were at their peak, while infiltrative tuberculosis showed a direct correlation between ADA activity, the number of affected lung segments, and bacterial presence.
- The increase in ADA activity, particularly from its isoenzyme ADA-2, suggests it could serve as a valuable indicator for assessing lung disease severity and treatment effectiveness during antituberculous therapy.
Article Abstract
An examination of 144 patients with different forms of pulmonary tuberculosis has revealed that serum adenosine deaminase (ADA) has a higher activity in the patients than in healthy individuals (a control group). The level of its activity is in proportion to the severity of a pulmonary process and achieves its peak in caseous pneumonia. In infiltrative tuberculosis, there is a direct relationship between the activity of ADA, the number of involved segments and bacterial isolation. The activity of ADA has been shown to be increased by its isoenzyme ADA-2. The unidirectional changes in the activity of ADA and the clinical and X-ray characteristics of the disease treated with antituberculous drugs make it possible to recommend this parameter as an additional criterion for evaluating the specific features of a process in the lung and the adequacy of therapy.
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