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Risk of cardiovascular disease following degarelix versus gonadotropin-releasing hormone agonists in patients with prostate cancer: a systematic review and meta-analysis.
Urol Oncol
January 2025
Department of Rheumatology, Stanford University Medical Center, CA.
Background: Prostate cancer treatment involves hormonal therapies that may carry cardiovascular risks, particularly for long-term use. Gonadotropin-releasing hormone (GnRH) antagonists, such as degarelix, may offer advantages over agonists, but comprehensive comparative cardiovascular outcomes are not well established. This study aimed to systematically review and analyze the cardiovascular safety profiles of degarelix compared to those of traditional GnRH agonists, providing critical insights for optimizing treatment strategies.
View Article and Find Full Text PDFTowards healthy sleep environments: Ambient, indoor, and personal exposure to PM and its implications in children's sleep health.
Environ Res
January 2025
Department of Civil, Environmental, & Architectural Engineering, Worcester Polytechnic Institute, Worcester, MA, United States. Electronic address:
The growing impact of climate change and escalating wildfire seasons has led to heightened ambient air pollution, potentially affecting children's sleep health. However, current epidemiological research often relies on outdoor weather data to model the environmental impacts on sleep health, potentially mischaracterizing the actual bedroom environment. To address these challenges, we conducted experiments to investigate the relationships among ambient, indoor, and personal exposure to PM concentrations and obstructive sleep apnea (OSA) in children.
View Article and Find Full Text PDFSex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children.
Biol Psychiatry
January 2025
MIND Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Background: Fine motor challenges are prevalent in autistic populations. However, little is known about their neurobiological underpinnings or how their related neural mechanisms are influenced by sex. The dorsal striatum, comprised of the caudate nucleus and putamen, is associated with motor learning and control and may hold critical information.
View Article and Find Full Text PDFAssessing the impact of e-cigarettes on human barrier systems: a systematic review.
Transl Res
January 2025
Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy. Electronic address:
The use of e-cigarettes has grown rapidly in recent years, raising concerns about their impact on human health, particularly on critical physiological barriers such as the blood-brain barrier (BBB), alveolar-capillary barrier, and vascular systems. This systematic review evaluates the current literature on the effects of e-cigarette exposure on these barrier systems. E-cigarettes, regardless of nicotine content, have been shown to induce oxidative stress, inflammation, and disruption of tight junction proteins, leading to impaired barrier function.
View Article and Find Full Text PDFDetailed analysis of air pollution in the Canadian prairie region: A step toward net-zero emission.
Sci Total Environ
January 2025
Faculty of Business Administration, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
Industrial, agricultural, and natural pollution pose a critical problem for the Prairie provinces of Canada, with significant environmental and health concerns. This study addresses a critical knowledge gap by assessing the cumulative impacts of pollutants in the Prairie region, which hosts 40 % of the Canada's indigenous population, often living near these pollution sources. By innovatively integrating Sentinel-5P satellite data, Google Earth Engine, ArcGIS, and Python, we show the trends in CO, NO₂, HCHO, SO₂, and aerosols from 2019 to 2023 at high resolution for the entire region, which sheds new light on the dynamics that operate beyond conventional air quality monitoring.
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