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Cost effectiveness of different treatment strategies with natalizumab for pregnant women with multiple sclerosis.
J Neurol
January 2025
Care Policy and Evaluation Centre, London School of Economics and Political Science, London, WC2A 2AE, UK.
Background: The management of multiple sclerosis (MS) during pregnancy poses significant challenges. This study aimed to evaluate the cost-effectiveness of three natalizumab treatment strategies during pregnancy from the UK healthcare system's perspective.
Methods: A Markov model was developed to assess the health outcomes and costs associated with three treatment strategies: continuous natalizumab treatment throughout pregnancy, treatment until the first trimester followed by discontinuation, and discontinuation at conception with resumption post-pregnancy.
No Vaccine, No Organ? Ethics of Vaccine Mandates for Pediatric Transplant.
Pediatr Transplant
February 2025
Departments of Health Humanities and Bioethics, Philosophy, Pediatrics, and Neurology, University of Rochester, Rochester, New York, USA.
Many transplant programs worldwide are likely to impose vaccine mandates for pediatric solid organ transplant candidates; some already do. Three potential benefits that advocates invoke to justify mandates are improved patient outcomes, efficient organ allocation, and contributions to community protection. We show that none of these benefits can justify mandates.
View Article and Find Full Text PDFContingency management (CM), an evidence-based behavioral strategy that rewards positive behavior change including tobacco cessation, is rarely offered to support people with HIV (PWH) who smoke. In this study, we explored perspectives among patients and research staff engaged in a multi-site randomized clinical trial involving clinical pharmacist-delivered CM within HIV clinics. Between February and September 2023, we conducted 1:1 interviews with 12 PWH randomized to receive CM and one focus group with 8 staff (i.
View Article and Find Full Text PDFMarijuana Use Increases the Risk of Postoperative Bleeding in Patients Undergoing Abdominal Body Contouring.
Aesthetic Plast Surg
January 2025
Division of Plastic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 600 Northern Boulevard, Great Neck, NY, 11021, USA.
Background: The legalization and changing perception of marijuana have led to a significant increase in its use. Although studies exploring marijuana's physiological effects have grown, its effect on surgical outcomes remains unclear. This study investigates the influence of marijuana consumption on postoperative complications in patients undergoing abdominal body contouring surgeries such as abdominoplasties and panniculectomies.
View Article and Find Full Text PDFQuality assessment of clinical practice guidelines and position statements on vital pulp therapy: a systematic review.
Evid Based Dent
January 2025
Division of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Objective: To evaluate different Clinical Practice Guidelines (CPGs) and Position Statements (PS) on Vital Pulp Therapy (VPT) using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) and Appraisal of Guidelines for Research and Evaluation-Recommendation EXcellence (AGREE-REX) tools.
Methods: Two authors performed the initial search using a set of keywords in six databases. Only CPGs and PS on VPT published during the past five years were included.
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