In a screening of basidiomycete cultures from Chile for the production of antibiotics we identified a Serpula himantoides strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four new antibiotics. Their structures were elucidated by spectroscopic methods. All four compounds are succinimide and maleimide derivatives, of which two are N-hydroxylated.
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High variability in a mating type linked region in the dry rot fungus Serpula lacrymans caused by frequency-dependent selection?
BMC Genet
July 2010
Microbial Evolution Research Group, Department of Biology, University of Oslo, PO Box 1066 Blindern, N-0316 Oslo, Norway.
Background: The mating type loci that govern the mating process in fungi are thought to be influenced by negative frequency-dependent selection due to rare allele advantage. In this study we used a mating type linked DNA marker as a proxy to indirectly study the allelic richness and geographic distribution of mating types of one mating type locus (MAT A) in worldwide populations of the dry rot fungus Serpula lacrymans. This fungus, which causes serious destruction to wooden constructions in temperate regions worldwide, has recently expanded its geographic range with a concomitant genetic bottleneck.
View Article and Find Full Text PDFThe himanimides, new bioactive compounds from Serpula himantoides (Fr.) Karst.
Z Naturforsch C J Biosci
July 2002
Universidad de Conception, Casilla, Chile.
In a screening of basidiomycete cultures from Chile for the production of antibiotics we identified a Serpula himantoides strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four new antibiotics. Their structures were elucidated by spectroscopic methods.
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