Aims: To establish the burden of co-morbid disease using the Charlson Index among hospital inpatients and its relationship to key health outcomes.
Methods: An initial screen was carried out on 1575 medical records selected by systematic list sample from admissions for 1995 in three public hospitals in the Auckland region. In the course of the administration of the instrument, screeners were required to record the occurrence of co-morbid disease using the Charlson Index.
Results: A third of patients had co-morbid disease, of which chronic pulmonary disease and congestive heart failure were the most frequently recorded. While the Charlson Index was associated with age of patient, length of stay, inpatient mortality, and adverse event status, the simple presence or absence of co-morbidity was as an effective predictor as the extended index. Co-morbidity was more likely to be recorded for Maori, for patients from deprived areas, and for circulatory or respiratory diagnoses. Specific co-morbid conditions were predictive of health outcomes.
Conclusions: Levels of co-morbid disease established for patients using the Charlson Index in three Auckland public hospitals are similar to those recorded internationally. Co-morbidity is predictive of key health outcomes that are of clinical and managerial significance. Controlling for co-morbidity will be important in making comparisons of the quality of care.
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Eur J Clin Invest
January 2025
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
From 1999 to 2020, age-adjusted mortality rates (AAMR) for atrial fibrillation-related deaths among U.S. adults (age ≥25) with comorbid diabetes mellitus increased significantly with an annual percent change of 6.
View Article and Find Full Text PDFEye (Lond)
January 2025
Princess Alexandra Eye Pavilion, Chalmers St, Edinburgh, EH3 9HA, UK.
Objective: To address the paucity of long-term data on outcomes following rhegmatogenous retinal detachment (RRD) repair we aimed to establish the 10-year best corrected visual acuity (BCVA), redetachment rate and lens status for patients from the Scottish Retinal Detachment Study.
Subjects: Data from patients who presented with RRD during the original study were collected from clinical records 10 years after repair. Patients were excluded if lacking 10 year follow-up data, and excluded from visual acuity analysis in the case of significant co-morbid ophthalmic disease.
Stem Cell Reports
January 2025
Toronto General Hospital Research Institute, University Health Network, 101 College St., Toronto, ON M5G 1L7, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada; Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada; Ajmera Transplant Center, University Health Network, Toronto, ON, Canada. Electronic address:
People with type 2 diabetes (T2D) are at a higher risk for myocardial infarction (MI) than age-matched healthy individuals. Here, we studied cell-based cardiac regeneration post MI in T2D rats modeling the co-morbid conditions in patients with MI. We recapitulated the T2D hallmarks and clinical aspects of diabetic cardiomyopathy using high-fat diet and streptozotocin in athymic rats, which were then subjected to MI and intramyocardial implantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with or without rat adipose-derived microvessels (MVs).
View Article and Find Full Text PDFJ ECT
January 2025
From the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
Background: Electroconvulsive therapy (ECT) is an effective treatment for treatment-resistant depression (TRD). There are limited data on the improvement of anxiety symptoms in patients receiving ECT for TRD.
Objective: The aim of the study was to examine the extent to which anxiety symptom severity improves, relative to improvements in depressive symptoms, in TRD patients receiving an acute course of ECT.
Aliment Pharmacol Ther
January 2025
Division of Gastroenterology, Hepatology, and Nutrition, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Background: Obesity has been linked to a more severe phenotype in patients with ulcerative colitis (UC).
Aim: To evaluate the impact of obesity on outcomes of advanced therapies in UC.
Methods: We conducted a retrospective cohort study utilising the TriNetX database comparing the composite score of corticosteroid use, change in advanced therapy or colectomy within two years between two cohorts of patients with UC-those with obesity (BMI ≥ 30 kg/m) and those without (BMI 18.
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