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meningitis in a patient with newly diagnosed acquired immunodeficiency syndrome from Sikkim, India.
Curr Med Mycol
May 2024
Department of Microbiology, Sikkim Manipal Institute of Medical Science, Gangtok, India.
Background And Purpose: infections in India have shifted, with an increase in the incidence rate of invasive candidiasis, particularly due to non- species. The central nervous system infections by are sparsely reported and more understanding and research is needed regarding these infections.
Case Report: This study reported an unusual case of meningitis in a middle-aged female with pulmonary tuberculosis and newly diagnosed acquired immunodeficiency syndrome with a low cluster of differentiation 4 count (12 cells/mm).
Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in during thermal stress.
mBio
December 2024
Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
The fungus is an opportunistic pathogen of humans that reprograms its translatome to facilitate adaptation and virulence within the host. We studied the role of Hog1/p38 in reprogramming translation during thermal stress adaptation and found that this pathway acts on translation crosstalk with the Gcn2 pathway, a well-studied regulator of general translation control. Using a combination of molecular assays and phenotypic analysis, we show that increased output from the Gcn2 pathway in a Hog1 deletion mutant is associated with rescue of thermal stress adaptation at both molecular and phenotypic scales.
View Article and Find Full Text PDFAn Update on Fungal Disease Outbreaks of Public Health Concern.
Infect Dis Clin North Am
December 2024
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
For this narrative review, we describe recent high-profile and severe outbreaks of emerging fungal infections, emphasizing lessons learned and opportunities to improve future prevention and response efforts. Several themes and challenges remain consistent across a diverse array of fungal outbreaks, including the multidisciplinary need for improved diagnostic testing to determine species and perform antifungal susceptibility testing, clinical awareness, and optimization of antifungal use. Recent outbreaks exemplify the growing promise of non-culture-based tools in identifying fungal outbreaks and improving responses, although access remains limited.
View Article and Find Full Text PDFMonitoring of the cerebrospinal fluid voriconazole level in a patient with recurrent Candida meningitis after pituitary surgery.
Int J Antimicrob Agents
December 2024
Department of Infectious Diseases and Clinical Microbiology, Turkiye Hacettepe University Faculty of Medicine, Ankara, Turkiye.
Meningitis caused by in a patient with liver cirrhosis: A case report and review of the literature.
Med Mycol Case Rep
December 2024
Department of Pathology and Laboratory Medicine, King Abdulaziz Hospital, Ministry of the National Guard-Health Affairs, AlAhsa, Saudi Arabia.
Unlabelled: Candida meningitis is almost always caused by , but other species, such as , can cause it on rare occasions. is increasingly linked to immunocompromised hosts but also affects immunocompetent hosts. To the best of our knowledge, we present the ninth (9th) case of meningitis, the first from Saudi Arabia.
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