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Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors. | LitMetric

Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors.

Carbohydr Res

Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.

Published: June 2002

AI Article Synopsis

  • * The research focuses on creating glucopyranoside analogues of adenophostin A that omit the adenine part, employing a specific synthetic strategy involving glycosylation.
  • * Two new trisphosphate analogues were developed: ribophostin and furanophostin, with the latter also yielding a novel phosphorothioate-containing version, marking a significant advancement in adenophostin analogues.

Article Abstract

Adenophostins A and B are naturally occurring glyconucleotides that interact potently with receptors for D-myo-inositol 1,4,5-trisphosphate, an important second messenger molecule in most cell types. Here we describe the design and synthesis of glucopyranoside-based analogues of adenophostin A lacking the adenine component. The key synthetic strategy involves glycosylation of selectively protected alcohols, derived from methyl beta-D-ribofuranoside or 1,4-anhydroerythritol, using glycosyl donors synthesised from 2,6-di-O-benzyl-D-glucopyranose derivatives. Further elaboration and deprotection of the coupled products gave two trisphosphate analogues; methyl 3-O-alpha-D-glucopyranosyl-beta-D-ribofuranoside 2,3',4'-trisphosphate ("ribophostin") and (3'S,4'R)-3'-hydroxytetrahydrofuran-4'-yl alpha-D-glucopyranoside 3,4,3'-trisphosphosphate ("furanophostin"). The route to furanophostin was further modified to give (3'S,4'R)-3'-hydroxytetrahydrofuran-4'-yl alpha-D-glucopyranoside 3'-phosphate 3,4-bisphosphorothioate, the first phosphorothioate-containing adenophostin analogue.

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Source
http://dx.doi.org/10.1016/s0008-6215(02)00103-9DOI Listing

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