Purpose: The purpose of this study is to clarify the relationship between retinal vascular obstruction and asymptomatic cerebral infarction (ACI).
Methods: Forty-three patients (27 men and 16 women) with retinal vascular obstruction were examined by magnetic resonance imaging (MRI) at the Department of Ophthalmology of Nagasaki University Hospital in Nagasaki, Japan. Patients with a history of neurological signs and symptoms were excluded from this study. The control group consisted of 93 male and 49 female patients who were examined by MRI for routine brain screening examinations at the Takaki Neurosurgical Clinic in Fukuoka, Japan. We investigated the incidence of ACI, and the risk factors and characteristics of this condition.
Results: ACI was more common in patients with retinal vascular obstruction than in normal adults at all ages. The incidence of hypertension in the patients with ACI tended to be higher than in the patients without ACI.
Conclusion: ACI appears more frequently in patients with retinal vascular obstruction than in normal adults. Our results indicate that either retinal artery occlusion or retinal vein occlusion should be considered a sign of ACI and systemic diseases such as arteriosclerosis.
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http://dx.doi.org/10.1016/s0021-5155(01)00500-7 | DOI Listing |
Mol Ther
January 2025
Department of Molecular Medicine, University of Southern Denmark; Odense, 5230, Denmark. Electronic address:
Neovascular age-related macular degeneration and diabetic macular edema are leading causes of vision-loss evoked by retinal neovascularization and vascular leakage. The glycoprotein microfibrillar-associated protein 4 (MFAP4) is an integrin αβ ligand present in the extracellular matrix. Single-cell transcriptomics reveal MFAP4 expression in cell-types in close proximity to vascular endothelial cells including choroidal vascular mural cells and retinal astrocytes and Müller cells.
View Article and Find Full Text PDFJ AAPOS
January 2025
University of Health Sciences, Department of Ophthalmology, Başakşehir Cam and Sakura City Hospital, Istanbul, Turkey.
Purpose: To use swept-source optical coherence tomography angiography (SS-OCTA) to investigate the alterations in retinal vascular density (VD) in patients presenting with congenital unilateral trochlear nerve palsy.
Methods: The medical records of patients diagnosed with congenital unilateral trochlear nerve palsy and those of a healthy control group were reviewed retrospectively. Comprehensive ocular examinations and SS-OCTA imaging were conducted.
Eur J Pharmacol
January 2025
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital. Electronic address:
Retinal vein occlusion (RVO) has become the second most common retinal vascular disease after diabetic retinopathy. Existing therapeutic approaches, including intravitreal injection of antivascular endothelial growth factors (anti-VEGFs) and/or glucocorticoids and laser therapy, primarily address secondary macular edema and neovascularisation. However, these strategies do not address the underlying cause of the disease and may have harmful side effects.
View Article and Find Full Text PDFViruses
December 2024
Department of Infectious Diseases and Hepatology, Medical University of Białystok, 15-540 Białystok, Poland.
The SARS-CoV-2 infection manifests with diverse clinical manifestations, with severity potentially influenced by the viral variant. COVID-19 has also been shown to impact ocular microcirculation in some patients, but whether this effect varies by viral lineage remains unclear. This prospective study compared clinical features and ocular parameters assessed via optical coherence tomography angiography (OCTA) in patients recovering from SARS-CoV-2 infections during the dominance of two distinctive viral lineages, Alpha (B.
View Article and Find Full Text PDFJ Clin Med
January 2025
Surgical Services, Miami Veterans Healthcare System, Miami, FL 33125, USA.
: This study aimed to evaluate the location of retinal fractal dimension (FD) abnormalities in individuals with diabetes mellitus (DM) and hypertension (HTN) without retinopathy. The annular zone of 6 mm × 6 mm OCTA images centered on the fovea was partitioned into thin annuli and analyzed using fractal analysis to measure FDs. The cohort ( = 114) had an average age of 55.
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