Two experiments document that conceptual knowledge influences 3-year-olds' extension of novel words. In Experiment 1, when objects were described as having conceptual properties typical of artifacts, children extended novel labels for these objects on the basis of shape alone. When the very same objects were described as having conceptual properties typical of animate kinds, children extended novel labels for these objects on the basis of both shape and texture. Moreover, providing a salient perceptual cue (Experiment 2) did not interfere with children's reliance on conceptual information in extending novel words: when an object with eyes was labeled with a novel word in the context of a story describing the object as an artifact, children extended the label on the basis of shape alone (i.e. as though the object were an artifact). These results, which challenge directly the position that 'dumb attentional mechanisms' can account for word learning, stand as evidence for the central role of conceptual information in mapping words to meaning.
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http://dx.doi.org/10.1016/s0010-0277(02)00016-1 | DOI Listing |
Br J Dev Psychol
January 2025
Department of Psychology, Trinity University, San Antonio, Texas, USA.
This study investigates whether the context in which a word is learnt affects noun and verb learning. There is mixed evidence in studies of noun learning, and no studies of background perceptual context in verb learning. Two-, three-, and four-year-olds (n = 162) saw a novel object moved in a novel way while hearing four novel words, either nouns or verbs.
View Article and Find Full Text PDFJ Clin Pharmacol
January 2025
Infectious Disease Research Collaboration, Kampala, Uganda.
Malaria and HIV co-infection are prevalent in sub-Saharan Africa causing significant drug interactions with co-treatment. We previously reported a 30%-70% reduction in exposure to the standard 3-day (6-dose) artemether-lumefantrine (AL) treatment for malaria when given with efavirenz-based HIV therapy, impacting malaria reinfection risk. We conducted a prospective, randomized study comparing the 3-day regimen to an extended 5-day (10-dose) regimen with pharmacokinetic sampling for artemether, dihydroartemisinin, lumefantrine, and desbutyl-lumefantrine (DBL) over 42 days.
View Article and Find Full Text PDFClin Oral Investig
January 2025
Rio de Janeiro State University, Rio de Janeiro, Brazil.
Aim: Assess the prevalence and severity of molar incisor hypomineralization (MIH) in children 6- to 12-year-old and correlate MIH severity with the complexity of treatment demands.
Materials And Methods: Between March and October 2023, 2,136 children were screened for MIH by two calibrated examiners. MIH severity was categorized in mild, moderate, severe, and very severe.
Vaccines (Basel)
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Road, Beijing 102206, China.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and children. mRNA vaccines based on the lipopolyplex (LPP) platform have been previously reported, but they remain unapplied in RSV vaccine development. In this study, we developed a novel LPP-delivered mRNA vaccine that expresses the respiratory syncytial virus prefusion protein (RSV pre-F) to evaluate its immunogenicity and protective effect in a mouse model.
View Article and Find Full Text PDFNeurol Int
January 2025
Clinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
Background/objectives: ZNF711(Zinc finger protein 711) encodes a zinc finger protein of currently undefined function, located on the X chromosome. Current knowledge includes a limited number of case reports where this gene has been exclusively associated with X-linked intellectual disability (XLID). As far as we are aware, we report the first cases of epilepsy associated with this particular variant.
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