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A prominent cutaneous eruption as a harbinger for aggressive systemic disease: Gamma-delta T-cell lymphoma.
JAAD Case Rep
September 2024
Department of Dermatology, Medical University of Graz, Graz, Austria.
Gamma-delta T-cell large granular lymphocytic leukemia in the setting of rheumatologic diseases.
Front Cell Dev Biol
August 2024
Laboratory of Molecular Hematology, National Medical Research Center for Hematology, Moscow, Russia.
Article Synopsis
- T-cell leukemia from large granular lymphocytes (T-LGL leukemia) is a rare type of cancer, with γδT-LGL leukemia making up about 17% of cases and being linked to autoimmune diseases like rheumatoid arthritis (RA).
- A study analyzed 15 patients with γδT-LGL leukemia and rheumatologic diseases, finding that most had RA, with notable symptoms such as splenomegaly and neutropenia.
- The research highlighted that mutations were common, particularly in certain genes, and showed unusual characteristics of γδT-LGL leukemia, mainly affecting the spleen and not appearing in peripheral blood, prompting the need for further investigation into the relationship between this leukemia and RA.
T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature.
Biomedicines
April 2024
Laboratory of Clinical Research and Advanced Diagnostics, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero In Vulture, Italy.
Article Synopsis
- Lymphoproliferative diseases involve various types of malignant lymphocyte growth, making diagnosis challenging due to their diverse presentations and characteristics.
- Flow cytometry has emerged as a valuable tool for diagnosing T-cell disorders, particularly when the number of cancerous cells is low.
- A case study of a 55-year-old man with two distinct T-cell clones highlights the importance of accurate diagnostic methods, as the patient's quick decline prevented a conclusive identification of one of the clones.
Hepatosplenic Alpha-Beta T-Cell Lymphoma: A Challenging Diagnostic Entity.
J Hematol
April 2024
Department of Pathology, HCA East Florida, Fort Lauderdale, FL, USA.
Hepatosplenic T-cell lymphoma (HSTCL) is rare and clinically very aggressive T-cell lymphoma. The majority of cases harbor γδ T-cell receptors (TCRs); however, in some even rarer cases, tumor cells harbor αβ TCR. Recent studies suggest that αβ cases may have distinct morphological characteristics and demonstrate an even more aggressive course.
View Article and Find Full Text PDF[Successful cord blood transplantation for refractory gamma-delta hepatosplenic T-cell lymphoma developed during treatment of Crohn's disease].
Rinsho Ketsueki
February 2024
Department of Hematology, Nephrology, Rheumatology, Akita University Graduate School of Medicine.
The patient was a 21-year-old man who had been diagnosed with Crohn's disease and received infliximab and azathioprine six years earlier. He was admitted with fever and fatigue. Peripheral blood examination showed LDH 2,473 U/l and thrombocytopenia, and contrast-enhanced computed tomography (CT) showed hepatosplenomegaly.
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