AI Article Synopsis
- PTEN is a crucial tumor-suppressor gene whose mutations are linked to various cancers, including breast cancer.
- Reduced PTEN protein expression was observed in 38% of invasive breast cancers and 11% of in situ cases, with the highest frequency in stages II and III.
- The study indicates a correlation between reduced PTEN expression and aneuploidy, as well as similarities in expression patterns between in situ and invasive cancer components.
Article Abstract
PTEN is a tumor-suppressor gene with phosphatase activity that is mutated in a variety of cancers. We analyzed a series of 34 invasive and 18 in situ breast cancers with known molecular status of the PTEN genotype using immunohistochemistry. Reduced PTEN protein expression was seen in 38% of invasive cancers and in 11% of in situ cancers. The frequency of reduced expression was highest in stage II and III cancers. Reduced expression also correlated with aneuploidy. In addition, in tumors with both in situ and invasive components, expression within the ductal carcinoma in situ portion tended to reflect the expression pattern of the invasive component. These data suggest that PTEN expression is frequently reduced in advanced breast cancers.
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| http://dx.doi.org/10.1053/hupa.2002.124721 | DOI Listing |
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