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Herpetic Endotheliitis Induced Interface Fluid Syndrome 16 years After Laser in Situ Keratomileusis.
Cornea
January 2025
Cornea Service, Wills Eye Hospital, Philadelphia, PA.
Purpose: To report a case of herpes simplex virus (HSV) endotheliitis inducing acute interface fluid syndrome in a patient with a remote history of laser in situ keratomileusis (LASIK).
Methods: Case report and literature review.
Results: A 51-year-old man with a history of LASIK 16 years prior presented with unilateral HSV endotheliitis and was found to have acute interface fluid syndrome secondary to endothelial decompensation.
Follow-Up of Infants With Congenital Cytomegalovirus Following Maternal Primary Infection in the First Trimester and Normal Fetal Brain Imaging at Midgestation.
Prenat Diagn
December 2024
Obstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Objective: To determine outcomes at birth and postnatal sequelae of congenital cytomegalovirus (cCMV) infection following maternal primary infection in the first trimester with normal fetal brain imaging at midgestation.
Methods: A retrospective, single-center cohort study was conducted, including all cases of proven cCMV infection following maternal primary infection in the first trimester from 2014 until 2021 and normal fetal brain imaging before 22 weeks of gestation. All pregnancies were followed according to our protocol, which offers amniocentesis at least 8 weeks after the onset of infection, serial ultrasound scans, and a fetal MRI in the third trimester.
Antiviral therapy for cytomegalovirus retinitis: A systematic review and meta-analysis.
Surv Ophthalmol
January 2025
Programme for Ocular Inflammation & Infection Translational Research, National Healthcare Group, Singapore, Singapore; Department of Bioinformatics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, UK; UCL-Institute of Ophthalmology, UK; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Duke NUS Medical School, Singapore; Singapore Eye Research Institute, Singapore.
Article Synopsis
- Cytomegalovirus retinitis (CMVR) is a major cause of blindness in advanced AIDS patients, with varied treatment approaches due to the lack of established guidelines.
- A review of 59 studies revealed an 18% improvement in visual acuity and a 90% rate of inflammation resolution, with ganciclovir being the most commonly used antiviral treatment.
- Notably, patients on antiretroviral therapy (ART) had a significantly lower recurrence rate of inflammation compared to those not on ART, and the most common side effect reported was neutropenia related to ganciclovir.
Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander?
Case Rep Ophthalmol
November 2024
Department of Ophthalmology, University of Florida, Gainesville, FL, USA.
Article Synopsis
- Phlyctenular keratoconjunctivitis is an inflammatory eye condition caused by a type IV hypersensitivity reaction, characterized by inflamed nodules, and can progress to more severe issues like nodular scleritis, particularly in patients with underlying infections like HSV-2.
- A 66-year-old woman initially diagnosed with keratoconjunctivitis displayed symptoms that progressed to conjunctival phlyctenule, where HSV-2 was identified as a contributing factor, and her condition improved significantly with oral antiviral treatment.
- This case emphasizes the need for proper diagnosis and treatment options for ocular inflammatory diseases, advocating for thorough testing and close follow-up to ensure effective management and personalized care for patients.
Higher dose antiviral therapy for herpes infections is associated with a risk of serious adverse events in older adults with chronic kidney disease.
Pharmacol Res Perspect
December 2024
ICES Western, London, Ontario, Canada.
Antiviral use has been linked to encephalopathy and elevated serum creatinine concentrations in individuals with chronic kidney disease (CKD) in case reports. Using linked healthcare data in Ontario, we conducted a population-based cohort study on adults aged ≥66 years not receiving dialysis and newly prescribed oral acyclovir, valacyclovir, or famciclovir in the outpatient setting (2008-2022) at higher versus lower doses. The primary composite outcome, a hospital visit with encephalopathy or acute kidney injury (AKI) within 14 days of initiating antiviral treatment, was examined in a primary cohort.
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