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Clinical characteristics and genomic changes of recurrent Methicillin-Resistant Staphylococcus aureus bacteremia.
J Microbiol Immunol Infect
November 2024
Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, 333, Taoyuan, Taiwan; Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, 333, Taoyuan, Taiwan; Chang Gung University School of Medicine, 333 Taoyuan, Taiwan. Electronic address:
Background: Recurrent or persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia presents significant clinical challenges. Comprehensive genomic-scale studies on the genetic changes in MRSA that correspond to refractory bacteremia are lacking.
Method: From 2011 to 2019, MRSA blood isolates were collected from patients with persistent or recurrent bacteremia at a teaching hospital in southern Taiwan.
Prevalence, virulence potential, antibiotic resistance profile, heavy metal resistance genes of Listeria innocua: A first study in consumed foods for assessment of human health risk in Northern Turkey.
Environ Sci Pollut Res Int
December 2024
Department of Medical Microbiology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Article Synopsis
- Listeria innocua is usually harmless but can become a threat for those with weak immune systems; it serves as a vital marker for food safety and sanitation effectiveness.
- A study collected 39 L. innocua strains from foods like beef, fish, milk, and cheese in Turkey, identifying several virulence genes and high levels of antibiotic resistance, particularly to fusidic acid and oxacillin.
- Results indicate that all isolates were resistant to at least one antibiotic, with most being multidrug resistant, emphasizing the need for better monitoring of L. innocua for potential risks to human and animal health.
Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform.
Front Pharmacol
October 2024
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, United States.
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy homeostasis. It is important to identify compounds that may modulate PXR activity to prevent drug-drug interactions, distinguish chemicals which could potentially generate toxicity, and identify compounds for further development towards therapeutic usage.
View Article and Find Full Text PDFJointly considering multi-medium and full-cycle to better reveal distribution and removal of antibiotic resistance genes in long-term constructed wetland.
Sci Total Environ
December 2024
College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:
Constructed wetlands (CWs) have been proven to effectively remove antibiotic resistance genes (ARGs) at different experimental scales; however, there is still a lack of researches on the removal and monitoring of ARGs during the actual operation of full-scale CWs. To fill this gap, this study selected the Annan constructed wetland in Beijing as a case study and utilized quantitative sequencing, metagenomic analysis, and other technical methods to determine characteristics of ARGs in CWs during different operating periods. Furthermore, we analysed the overall removal characteristics of ARGs in the CW during different operating periods and differences of ARG distribution in three media.
View Article and Find Full Text PDF[Special lesion on back of the hand].
Ned Tijdschr Geneeskd
October 2024
Rijnstate, afd. Dermatologie, Arnhem.
Article Synopsis
- A 74-year-old healthy man presented with a two-month-old asymptomatic hand lesion, which was initially treated with topical creams but required further evaluation.
- A biopsy revealed cutaneous leishmaniasis tropica, likely contracted during his travels to Mediterranean regions such as Greece and Spain, where the disease is prevalent.
- The condition was successfully treated with cryotherapy and antimony injections, highlighting the need to consider travel history in diagnosing dermatological issues linked to endemic diseases.
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