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Clinical Characteristics and Treatment Outcomes in Unilateral Coats disease - a Global Collaborative Study.
Ophthalmol Retina
November 2024
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Purpose: To evaluate the clinical outcomes and prognostic factors in unilateral Coats disease in the era of anti-VEGF therapy.
Design: Global, multicenter, retrospective case series.
Subjects: 656 eyes of 656 subjects with Coats disease were included in this study.
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults.
Am J Physiol Heart Circ Physiol
January 2025
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
Insulin has important vasodilatory effects in the peripheral circulation, but less is known about insulin's role in cerebrovascular control. Herein, we hypothesized both systemic (intravenous) and local (intranasal) insulin administration would increase indices of cerebral blood flow and reduce cerebrovascular compliance (Ci) in young adults. Participants were assigned to one of four separate protocols.
View Article and Find Full Text PDFOvercoming challenges of prescribing long-term opioid therapy in residency clinics.
J Opioid Manag
September 2024
John's Family Medicine Residency Program, Department of Family Medicine and Commu-nity Health, University of Minnesota Medical School, Minneapolis, Minnesota. ORCID: https://orcid.org/0000-0003-1051-6281.
Objectives: To describe the impact of a standardized opioid prescribing intervention when implemented in three family medicine (FM) residency training - clinics-environments that face operational challenges including regular resident turnover.
Design: We performed a retrospective cohort study to compare patterns of long-term opioid prescribing between residency and nonresidency clinics.
Setting: This study took place within a large, academic, health system.
Inuit birthing in the Qikiqtaaluk Region of Nunavut: A place-based inquiry of maternity care systems.
Health Place
November 2024
Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada. Electronic address:
Many Indigenous People in Northern and remote areas need to travel away from home for childbirth; however, their birthing traditions and practices are intimately tied to place. This qualitative research study characterized Inuit childbirth experiences and recommendations to enhance birthing supports in the Qikiqtaaluk Region of Nunavut in Inuit Nunangat, Canada. Birthing experiences were profoundly shaped by relationships and place attachment, and recommendations related to increased Inuit involvement in maternity care systems.
View Article and Find Full Text PDFEffect of endothelin-1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men.
Physiol Rep
September 2024
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
Endothelin-1 (ET-1) and its receptors are linked to increases in sensitivity of the chemoreceptors to hypoxic stress and the development of hypertension in preclinical models. We hypothesized ET receptor antagonism would lower resting blood pressure (BP) as well as the acute BP response to chemoreflex stress. Twenty-four men (31 ± 5 years, 26 ± 3 kg/m) completed two study visits (control, bosentan).
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