The naturally occurring sesquiterpene squamulosone (1), isolated from Hyptis verticillata (Labiatae), was synthetically reduced to five analogues that were identified as (1S,10S)-9alpha-hydroxy-allo-aromadendrane (2), (1R,10R)-9beta-hydroxyaromadendrane (3), (1S,10S)-allo-aromadendran-9-one (4), (1R,10R)-aromadendran-9-one (5) and aromadendra-1,9-diene (6). Each congener was incubated with the fungus Curvularia lunata ATCC 12017 in two different growth media. All the substrates except the deoxy compound 6 underwent a simple redox reaction. Ketone 5 additionally experienced remote hydroxylation while analogue 6, possessing a conjugated diene system, was most extensively metabolised. The substrates and products presented here, but one, are all novel.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0031-9422(02)00136-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mycoremediation of heavy metals by Curvularia lunata from Buckingham Canal, Neelankarai, Chennai.
World J Microbiol Biotechnol
December 2024
Department of Biotechnology, School of Life Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.
The spread and mobilization of toxic heavy metals in the environment have increased to a harmful level in recent years as a result of the fast industrialization occurring all over the world to meet the demands of a rising population. This research aims to analyze and evaluate the mycoremediation abilities of fungal strains that exhibit tolerance to heavy metals, gathered from water samples at Buckingham Canal, Neelankarai, Chennai. Water samples were examined for heavy metal analysis, and the highest toxic heavy metals, Zn, Pb, Mn, Cu, and Cr, were recorded.
View Article and Find Full Text PDFIn Vitro Biological Activities of an Endophytic Fungus, sp. L2D2 Isolated from .
Indian J Microbiol
December 2024
Department of Life Sciences (Botany), Manipur University, Canchipur, Manipur 795003 India.
The endophytic fungus, sp. L2D2 was isolated from the medicinal plant and has been assessed for extracellular enzyme production, plant growth promotion, antifungal, antibacterial, and antioxidant activities in vitro. The endophyte has been found to produce amylase, cellulose, and ammonia qualitatively.
View Article and Find Full Text PDFAntiproliferative effects of resorcylic acid lactones from the Beibu Gulf coral-derived fungus GXIMD 02512 on prostate cancer cells.
RSC Adv
December 2024
Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi Institute of Marine Drugs, Guangxi University of Chinese Medicine Nanning 530200 China
Four novel resorcylic acid lactones (RALs), curvulomycins A-D (1-4), and six known congeners were isolated from the Beibu Gulf coral-derived fungus GXIMD 02512. Their structures including absolute configurations were established by extensive spectroscopic analyses along with experimental and calculated ECD spectra. Structurally, compound 3 harbors a unique γ-pyrone moiety rarely found in the natural RAL family.
View Article and Find Full Text PDFThe green shield: role in sustainable agriculture against soil-borne fungal threats.
Curr Res Microb Sci
November 2024
Section of Mycology and Plant Pathology Laboratory, Department of Botany, University of Kashmir, Srinagar 190006, India.
Article Synopsis
- - Soil-borne pathogenic fungi significantly reduce plant yields and pose environmental risks when controlled chemically, leading to a focus on biological methods for disease management.
- - This study isolated various species from 25 soil samples and assessed their ability to inhibit the growth of 12 different soil-borne fungal pathogens using a dual culture technique.
- - The results showed that higher concentrations of culture filtrates from selected species effectively reduced mycelial growth, suggesting these native species could serve as sustainable biocontrol agents against fungal diseases in plants.
Antifungal resistance, clinical outcome and clinico-microbiological correlation in ocular infections due to common melanized fungi and in South India.
J Med Microbiol
November 2024
Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034, India.
Melanized fungi were rarely studied for their antifungal resistance (AFR) or clinical outcome, despite rising incidence of melanized fungal ocular infections and AFR in general. We report the antifungal resistance patterns, clinical outcome and clinico-microbiological correlation in two commonly isolated melanized fungi from ocular infections, and , at a tertiary eyecare centre in South India..
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!