Objective: To identify clinically relevant variables and treatments for dogs bitten by prairie rattlesnakes (Crotalus viridis viridis).
Design: Retrospective study.
Animals: 100 client-owned dogs.
Procedure: Records of dogs evaluated for rattlesnake envenomation from 1989 to 1998 were reviewed. Analysis was performed to test for significant associations among clinical variables or treatments and cell counts, costs, and duration of hospitalization.
Results: Most prairie rattlesnake bites occurred between May and September. Dogs were 3 months to 12 years old (median, 3.7 years); most were bitten on the head in the late afternoon. There was no sex predilection. Median time to evaluation was 1 hour (range, 15 minutes to 13 hours). Swelling in the area of the bite was the primary physical abnormality. Principal initial laboratory findings were echinocytosis, thrombocytopenia, leukocytosis, and prolonged activated clotting time. Ninety-four dogs were hospitalized; 48 were discharged the following day. Antimicrobials and crystalloid fluids, glucocorticoids, antihistamines, and antivenin administered i.v. were the most commonly used treatments. One dog died, and small dogs were hospitalized longer than large dogs. Antivenin administration was not significantly associated with duration of hospitalization but was associated with higher platelet counts after treatment and higher total hospital costs.
Conclusions And Clinical Relevance: Prairie rattlesnake envenomation in dogs is associated with high morbidity rate but low mortality rate. The efficacy of administration of antivenin for dogs with bites from this snake species is questionable.
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http://dx.doi.org/10.2460/javma.2002.220.1675 | DOI Listing |
J Exp Biol
December 2024
Biological Sciences Department, California Polytechnic State University San Luis Obispo, 1 Grand Avenue, San Luis Obispo, California 93407, USA.
Viviparous snakes may be particularly vulnerable to predicted increases in drought due to the high hydric costs associated with embryonic development, gestation, and their reliance on limited free-standing bodies of water or rain events for hydration. Drought will have negative implications for viper populations if females become increasingly water-stressed and resorb developing embryos to conserve bodily water. We conducted a study to investigate the importance of drinking water in late-term pregnancy and its effect on cutaneous evaporative water loss (CEWL).
View Article and Find Full Text PDFJ Therm Biol
August 2024
Biology Department, Dickinson College, Carlisle, Pennsylvania, 17013, USA. Electronic address:
Temperature is a primary factor influencing organismal development, and the fluctuating daily and seasonal thermal regimes of temperate climates may challenge the ability of viviparous reptiles to optimize body temperatures during gestation. Testing how viviparous reptiles navigate highly variable thermal conditions (e.g.
View Article and Find Full Text PDFGenome Biol Evol
July 2024
Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.
Understanding and predicting the relationships between genotype and phenotype is often challenging, largely due to the complex nature of eukaryotic gene regulation. A step towards this goal is to map how phenotypic diversity evolves through genomic changes that modify gene regulatory interactions. Using the Prairie Rattlesnake (Crotalus viridis) and related species, we integrate mRNA-seq, proteomic, ATAC-seq and whole-genome resequencing data to understand how specific evolutionary modifications to gene regulatory network components produce differences in venom gene expression.
View Article and Find Full Text PDFClimate change has the potential to disrupt species interactions across global ecosystems. Ectotherm-endotherm interactions may be especially prone to this risk due to the possible mismatch between the species in physiological response and performance. However, few studies have examined how changing temperatures might differentially impact species' niches or available suitable habitat when they have very different modes of thermoregulation.
View Article and Find Full Text PDFBMC Genomics
February 2024
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Background: Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions between venom toxins from the medically significant snake families Elapidae and Viperidae, and toxin gene regulatory investigations in elapid snakes have been limited. Here, we used high-throughput RNA-sequencing to profile gene expression and microRNAs between active (milked) and resting (unmilked) venom glands in an elapid (Eastern Brown Snake, Pseudonaja textilis), in addition to comparative genomics, to identify cis- and trans-acting regulation of venom production in an elapid in comparison to viperids (Crotalus viridis and C.
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