Circadian variations of P.R.A. and angiotensin II were studied in three normal subjects and nine hypertensive patients. All data were analysed by a mathematical-statistical method called "cosinor". Analysis of results has shown: 1) Circadian rhythm of P.R.A. which in the normal subjects reaches its acrophase (maximum daily level) in the morning, while in the hypertensive patients the acrophase recurs in the afternoon; 2) Circadian rhythm of angiotensin II in the normal subjects, which is not detected in the hypertensive patients. Angiotensin I does not exhibit rhythm in both groups.
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