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CAR/CSACI Practice Guidance for Contrast Media Hypersensitivity.
Can Assoc Radiol J
January 2025
Department of Radiology, Dalhousie University, Halifax, NS, Canada.
Contrast media, including iodinated contrast media and gadolinium-based contrast agents, are commonly administered pharmaceuticals with excellent safety profiles. However, a minority of the population may experience a hypersensitivity reaction following intravenous administration. Hypersensitivity reactions can be immediate or delayed, and range from mild, such as urticaria, to severe, including anaphylaxis.
View Article and Find Full Text PDFAcute Torticollis Reaction Following Metoclopramide Use in a Pediatric Patient: A Comprehensive Case Report and Appraisal of Current Knowledge.
Int Med Case Rep J
December 2024
Faculty of Medicine, Mogadishu University, Mogadishu, Somalia.
Dopamine receptor antagonists like metoclopramide are frequently used in a variety of clinical contexts to treat gastrointestinal disorders and control nausea and vomiting. However, it is associated with a high incidence of extrapyramidal side effects (EPS) in children, including dystonic movements and torticollis. This is the instance of a 9-year-old girl who developed abnormal movements of the neck and tongue, along with torticollis, within 48 hours of receiving intravenous metoclopramide for gastroenteritis.
View Article and Find Full Text PDFSuccessful oral phytonadione (vitamin K) challenge following an infusion-related reaction to intravenous phytonadione.
BMJ Case Rep
November 2024
University of Iowa College of Pharmacy, Iowa City, Iowa, USA.
A woman in her early 60s presented to the emergency room with worsening pain 10 days after an injury to her right abdomen. CT revealed a large subcutaneous haematoma and contained small bowel perforation. She was tachycardic and anaemic and her international normalized ratio (INR) was 2.
View Article and Find Full Text PDFEpidemiology of headache presentations to United States emergency departments from 2016 to 2023.
Am J Emerg Med
November 2024
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Article Synopsis
- Headaches account for 3.2% of all ED visits, with 4.1% of those patients being admitted, highlighting them as a significant health issue.
- Nearly half of the headache patients underwent CT imaging, which has increased over time, while lumbar puncture procedures have decreased.
- The most commonly administered medications were NSAIDs and dopamine antagonists, and there's been a trend of reducing opioid use in favor of other treatments like intravenous fluids and acetaminophen.
Intravenous Cetirizine Premedication to Mitigate Infusion-Related Reactions.
J Adv Pract Oncol
March 2024
TerSera Therapeutics, Deerfield, Illinois.
Article Synopsis
- - Infusion-related reactions (IRRs) are common with therapies like chemotherapy and immunotherapy, and diphenhydramine has been the primary IV antihistamine used for over 60 years despite lacking FDA approval for this purpose.
- - In 2019, IV cetirizine was approved and offered a safer alternative with fewer side effects compared to diphenhydramine, proving equally effective in managing IRRs while potentially reducing treatment time and visits.
- - The FDA has required many infusion products to include premedication guidelines, suggesting that IV cetirizine should be actively considered for preventing and managing IRRs in clinical settings.
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