In mixed infection with Schistosoma mansoni and S. haematobium in hamsters, either simultaneously or after the full maturation of an initial infection with either schistosome species, a high level of acquired resistance was observed. The degree of immunity was magnified by the significant reduction in the number of eggs per gram tissue and hatchability of mature eggs. Some disturbance was also observed in the oogram pattern.
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Exp Parasitol
January 2025
Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt. Electronic address:
This study investigates whether Cerastes cerastes venom (CCV) administrated at different doses (3 and 6μg/mouse) and times (a week pre-infection, the first week post-infection, and the fifth week post-infection) possesses antischistosomal activity on Schistosoma mansoni infected mice. The results showed that treatment with half lethal dose (6 μg/mouse) of CCV, at various time schedules, led to a significant decrease in the total worm burden. However, quarter lethal dose (3μg/mouse) of CCV showed a significant decrease in the total worm burden only when administered a week pre-infection.
View Article and Find Full Text PDFVet Parasitol
January 2025
Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Schistosomiasis is a serious parasite disease with a high rate of mortality and negative financial impacts in subtropical and tropical locations like Egypt. The goal of this study was to investigate the anti-schistosomal effect of Spirulina platensis (SP) and Spirulina loaded niosomes (SPN), either in the presence or absence of praziquantel (PZQ) against S. mansoni in experimentally infected mice.
View Article and Find Full Text PDFMem Inst Oswaldo Cruz
June 2024
Universidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Biologia Parasitária, Natal, RN, Brasil.
J Helminthol
December 2023
Medical Parasitology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Schistosomiasis is a serious tropical disease. Despite extensive research into the etiology of liver fibrosis, effective therapeutic options remain limited. This study aims to assess the effectiveness of auranofin in treating hepatic granuloma and fibrogenesis produced by eggs.
View Article and Find Full Text PDFBiomedicines
August 2023
Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife 50740-520, PE, Brazil.
Schistosomiasis, a potentially fatal chronic disease whose etiological agents are blood trematode worms of the genus spp., is one of the most prevalent and debilitating neglected diseases. The treatment of schistosomiasis depends exclusively on praziquantel (PZQ), a drug that has been used since the 1970s and that already has reports of reduced therapeutic efficacy, related with the development of -resistant or -tolerant strains.
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