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Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes.
Curr Neurol Neurosci Rep
March 2025
Department of Neurology, University of New Mexico, MSC10-5620, Albuquerque, NM, 87131, USA.
Purpose Of Review: A deeper understanding of the communication network between the gut microbiome and the central nervous system, termed the gut-brain axis (GBA), has revealed new potential targets for intervention to prevent the development of neurodegenerative disease associated with tramatic brain injury (TBI). This review aims to comprehensively examine the role of GBA post-traumatic brain injury (TBI).
Recent Findings: The GBA functions through neural, metabolic, immune, and endocrine systems, creating bidirectional signaling pathways that modulate brain and gastrointestinal (GI) tract physiology.
VDAC1 Inhibition Mitigates Inflammatory Status and Oxidative Stress in Epileptic Mice Treated with the Ketogenic Diet.
Neurochem Res
March 2025
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Due to the pleiotropic effects of ketogenic diet (KD) on pathophysiology, including inflammation and oxidative stress, medical personnels have been intensively exploring the application of it in the management of epilepsy. Meanwhile, the voltage-dependent anion channel 1 (VDAC1) is believed to be involved in regulating inflammatory and oxidative stress processes. However, the correlation between KD and VDAC1 in epilepsy has not been elucidated.
View Article and Find Full Text PDFKetogenic metabolic therapy in the remission of chronic major depressive disorder: a retrospective case study.
Front Nutr
February 2025
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
Background: There is limited evidence describing the use of ketogenic metabolic therapy (KMT), also known as a ketogenic diet (KD), to achieve full remission of treatment-resistant major depressive disorder (MDD) in real-world clinical settings. This case study examines a 47-year-old woman with lifelong treatment-resistant MDD who achieved complete remission of depressive symptoms and improved functioning through a ketogenic diet.
Methods: The patient engaged in KMT with a 1.
Ketogenic Diet and Hepatic Ischaemia-Reperfusion Injury: Aggravation or Mitigation?
Liver Int
April 2025
Organ Transplant Center, Third Xiangya Hospital, Central SouthUniversity, Changsha, Hunan Province, China.
AI-Powered Analysis of Weight Loss Reports from Reddit: Unlocking Social Media's Potential in Dietary Assessment.
Nutrients
February 2025
Computer Simulation, Genomics and Data Analysis Laboratory, Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Greece.
: The increasing use of social media for sharing health and diet experiences presents new opportunities for nutritional research and dietary assessment. Large language models (LLMs) and artificial intelligence (AI) offer innovative approaches to analyzing self-reported data from online communities. This study explores weight loss experiences associated with the ketogenic diet (KD) using user-generated content from Reddit, aiming to identify trends and potential biases in self-reported outcomes.
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