Aim: To study the effects of preoperative regional artery chemotherapy (PRACT) in inducing growth inhibition and apoptosis of gastric carcinoma (GC) cells.
Methods: TUNEL (terminal-deoxynucleotidyl-transferase TdT-mediated dUTP-fluorescein and labeling) method and immunohistochemical techniques were used to detect the state of apoptosis and proliferation of GC cells in histopathologic sections. A total of 110 cases of GC and 68 cases of metastatic lymph node with or without PRACT were adopted. Correlations between apoptosis index (AI), proliferation index (PI) and PRACT and prognosis were analysed.
Results: The apoptosis index (AI) was significantly higher in the PRACT group (12.5 +/-4.33 ) than in the untreated group (7.1 +/-3.43 , P<0.001), whereas the proliferation index (PI) in the PRACT group (33.8%+/-8.8%) was significantly lower than that in untreated group (43.6%+/-12.8%, P<0.01). Both AI and PI were correlated to the differentiation degree of GC in PRACT group, the AI in the differentiated group was higher than that in undifferentiated group (P<0.001), but the PI was lower in the differentiated group than that of the undifferentiated group (P<0.01). The AI of GC cells in metastatic lymph node was also significantly higher in the PRACT group (7.9 +/-3.41 ) than in the untreated group (3.6 +/-2.93 , P<0.01), though the PI of GC cells in metastatic lymph nodes in the PRACT group (17.2%+/-6.8%) was significantly lower than that in the untreated group (26.7%+/-9.3%, P<0.01). The severity of histopathologic changes was significantly higher in the PRACT group than in the untreated group (P<0.05). In addition, postoperative surveys demonstrated that the 5-year survival rate of GC patients in the PRACT group was significantly higher than that of patients in the untreated group (P<0.01).
Conclusion: Preoperative regional artery chemotherapy (PRACT) showed inhibitory action on the growth of GC cells mainly through inhibiting proliferation and inducing the apoptosis of tumor cells. PRACT can improve the progno sis of GC patients also.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656419 | PMC |
| http://dx.doi.org/10.3748/wjg.v8.i3.451 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anatomical considerations for thread-based brow lifting and wrinkle treatment.
J Dermatolog Treat
December 2025
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
This review explores the anatomical considerations and technical aspects of thread lifting for the forehead and eyebrow, focusing on the relationships between vascular structures, muscular anatomy, and age-related changes in the forehead-eyebrow complex. It highlights the critical importance of understanding neurovascular pathways, particularly the supratrochlear and supraorbital vessels, as well as the appropriate thread placement techniques necessary for optimal outcomes. The review demonstrates that I-shaped threads, when placed beneath the frontalis muscle, provide a safer and equally effective alternative to traditional U-shaped designs.
View Article and Find Full Text PDFDifficult airway management in 25 hospitals across China: A multicenter cross-sectional study.
J Clin Anesth
January 2025
Department of Anaesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China. Electronic address:
Study Objective: Difficult airway management is a significant challenge in clinical anesthesia, critical care, and emergency medicine. Inadequate management can lead to severe complications including organ damage and death. This study assessed the variability in difficult airway management across China and focused on how patient and operator factors influenced outcomes in operating rooms.
View Article and Find Full Text PDFPhysical functioning before knee arthroplasty is not associated with (standardized) preoperative physiotherapy, but is tied to physical functioning 1-year post-surgery: A prospective cohort study.
J Orthop
August 2025
Centre for Orthopaedic Research Alkmaar (CORAL), Department of Orthopaedic Surgery, Northwest Clinics, Alkmaar, the Netherlands.
Background: and purpose This study investigates whether a (regionally) standardized physiotherapy approach, employing a stepped-care model, can more effectively enhance preoperative physical function in end-stage osteoarthritis (OA) patients undergoing total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) and improve postoperative outcomes, addressing the current gap in understanding the impact of such interventions.
Methods: This mono-center observational prospective cohort study followed 216 primary UKA or TKA patients for one-year post-surgery. Preoperative physiotherapy, recorded through self-reported questionnaires, included standardization and treatment frequency details.
Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis.
Intensive Crit Care Nurs
January 2025
Department of Environmental Engineering, Yildiz Technical University, İstanbul, Turkey.
Background: Surgical site infections (SSIs) are the most common postoperative complications after cesarean section (CS), with increased mortality, prolonged hospital stays, and increased healthcare costs.
Objective: To systematically estimate the global incidence and identify the risk factors associated with SSI, focusing on the variation between high- and low-income countries.
Search Strategy And Selection Criteria: Observational studies reporting on the incidence of SSI after CS were systematically searched in PubMed, Embase and SCOPUS.
Incidence and factors associated with postoperative headache among adult elective surgical patients at the university of gondar comprehensive specialized hospital, northwest Ethiopia, 2022: a prospective follow-up study.
BMC Anesthesiol
January 2025
Department of Anesthesia, School of Medicine, College of Medicine and Health sciences, University of Gondar, Gondar, Ethiopia.
Background: Postoperative headache is a medical condition that has a strong association with future recurrence and chronic headache, higher morbidity and mortality, extended hospital stays, poor quality of life and high financial burden. Despite, having these consequences, there are limited studies in the study area.
Objective: This study aimed to assess the incidence and associated factors of postoperative headache among adult elective surgical patients at the University of Gondar Comprehensive Specialized Hospital Northwest Ethiopia, April 9 to 20 June 2022.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!