We have already reported that the expression of HSP 70 in the adrenal gland was the most apparent among all organs in whole body-heated mice. In this paper, we examined the relation between the induction of HSP 70 and the adrenal gland using adrenalectomized mice. The expression of HSP 70 in some organs of adrenalectomized mice was significantly lowered in comparison with control mice. Adrenalectomy attenuated whole body heating-induced HSP 70 induction in some organs. Low expression of HSP 70 in adrenalectomized mice was a result to high-mortality caused by endotoxin shock. These results indicate that the adrenal gland plays an important role in the response to stress, leading to the induction of HSP 70.
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