Characterization of TT virus (TTV), the history of its discovery, taxonomy and identification are reviewed as update on the diagnostics of TTV infection with PCR. The variability of the virus and resulting difficulties in the selection of a TTV DNA fragment for amplification are described. Data on the virus prevalence, replication and persistence are given. The pathogenetic importance of TTV is discussed with the account of different concepts.
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Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
Nat Commun
December 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Article Synopsis
- The study investigates how gut microbial metabolites (GMM), specifically phenylacetylglutamine (PAGln), are linked to cardiovascular diseases (CVD) in people with alcohol use disorder.
- In experiments with mice, researchers found that chronic alcohol consumption led to changes in gut microbes and increased PAGln levels, which were associated with cardiovascular issues.
- PAGln was shown to cause heart and blood vessel problems independent of alcohol, indicating that it plays a significant role in the development of CVD related to alcohol consumption.
Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019-2020.
BMJ Paediatr Open
September 2024
National Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.
In Malawi, tetanus toxoid vaccination (TTV) is recommended in pregnancy, but few studies have assessed the prevalence of infant seroprotection against tetanus. Anti-TT levels from 84 6-week-old infants, born in 2019-2020 to mothers living with HIV (HEU: HIV-exposed-uninfected) infants and to HIV-negative women (HUU: HIV-unexposed-uninfected) infants were determined by ELISA assay. Although 94% of the infants (HEU=94.
View Article and Find Full Text PDFAmbient Temperature Effects on Hospitalization Risk Among Farmers: A Time-Series Study on Multiple Diseases in Vietnam.
J Occup Environ Med
April 2024
From the Center for Environment and Population Health, Griffith University, Brisbane, Australia (N.Q.L.T., C.C., H.P.); Graduate School of Public Health, International University of Health and Welfare, Narita, Japan (N.T.T.V.); Research School of Economics, The Australian National University, Canberra, Australia (S.N.); and School of Public Health, The University of Queensland, Brisbane, Australia (D.P.).
Objective: The aim of the study is to assess the effect of high temperatures on hospitalization for all causes and heat-sensitive diseases among Vietnamese farmers.
Methods: The Poisson generalized linear model and distributed lag nonlinear model were used to investigate the temperature-hospitalization association for all causes and seven cause-specific disease groups.
Results: Every 1°C increase in daily mean temperature above the threshold increased the estimated relative risk (95% CI) of all-cause hospitalization by 1.
Association of torque teno virus viremia with liver fibrosis in the first year after liver transplantation.
Front Immunol
August 2023
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Introduction: Torque teno virus (TTV) replication is controlled by immune status, mirroring a degree of immunosuppression after solid organ transplantation. TTV viraemia (TTVv) was associated with acute cellular rejection and infection within the first year after liver transplantation (LT). Long-term data on TTV after LT and correlation with graft injury from protocol biopsies are limited.
View Article and Find Full Text PDFChanges in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life.
Stroke
May 2023
Department of Vascular Medicine, University Medical Center Utrecht, the Netherlands (T.T.v.S.).
Background: Cardiovascular health may be used for prevention of cerebral vascular disease; however, data on the association of cardiovascular health across midlife and late-life with late-life cerebral vascular disease are lacking. Our aim was to examine whether midlife or late-life cardiovascular health as well as changes of cardiovascular health within midlife and between midlife and late-life were associated with prevalence of magnetic resonance imaging markers of cerebral vascular disease at late-life.
Methods: Prospective cohort study including 1638 participants from the Atherosclerosis Risk in Communities Study who took part in 2 visits at midlife (mean ages, 53 and 59 years), and a late-life visit (mean age, 76 years).
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