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Real-World Efficacy and Safety of Escalation to Weekly Adalimumab for Chronic Non-Infectious Uveitis: A Multicenter Study Involving Pediatric and Adult Patients.
Ocul Immunol Inflamm
January 2025
Department of Ophthalmology,University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Purpose: To evaluate the efficacy and safety of weekly adalimumab (ADA) treatment in non-infectious uveitis (NIU) patients, including both pediatric and adult populations, and identify factors influencing treatment efficacy.
Methods: A retrospective cohort study at two hospitals in Türkiye included 51 NIU patients (29 children, 22 adults) who escalated from bi-weekly to weekly ADA due to inadequate disease control. Data on six clinical parameters (anterior chamber reaction, vitreous haze, visual acuity, central macular thickness [CMT], prednisone use, uveitis flare-up frequency), adverse effects, and treatment-related factors were collected.
Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.
Front Aging Neurosci
January 2025
Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Purpose: Differentiating between Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be challenging due to overlapping cognitive and behavioral manifestations. Evidence regarding non-invasive and early-stage biomarkers remains limited. Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.
View Article and Find Full Text PDFResveratrol Supplementation in Wet AMD: Association With Fewer Intravitreal Injections and Reduced Macular Fibrosis.
Clin Ophthalmol
January 2025
2nd Department of Ophthalmology, Medical School of University of Athens, "attikon" University Hospital, Athens, Greece.
Purpose: To evaluate the 2-year outcomes of resveratrol oral supplement given as an adjunctive treatment in patients with wet age-related macular degeneration (AMD) that were treated with intravitreal injections of aflibercept.
Patients And Methods: In our retrospective study, 50 treatment-naïve patients suffering from wet-AMD were included. They were assigned to two subgroups of 25 patients each.
Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans.
Ophthalmol Sci
November 2024
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland.
Objective: To propose Deep-RPD-Net, a 3-dimensional deep learning network with semisupervised learning (SSL) for the detection of reticular pseudodrusen (RPD) on spectral-domain OCT scans, explain its decision-making, and compare it with baseline methods.
Design: Deep learning model development.
Participants: Three hundred fifteen participants from the Age-Related Eye Disease Study 2 Ancillary OCT Study (AREDS2) and 161 participants from the Dark Adaptation in Age-related Macular Degeneration Study (DAAMD).
EVALUATION OF MACULA GANGLION CELL ANALYSIS AND RETINAL NERVE FIBER LAYER THICKNESS IN PREPERIMETRIC GLAUCOMA, EARLY STAGE GLAUCOMA AND HEALTHY INDIVIDUALS.
Photodiagnosis Photodyn Ther
January 2025
Department of Ophthalmology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Purpose: In this study, it was planned to compare the macular ganglion cell analysis (GCA) and peripapillary retinal nerve fiber layer (pRNFL) of the patients with preperimetric glaucoma (PPG), early stage glaucoma (EG) and the control group.
Methods: This retrospective study included a total of 103 eyes: 38 from EG patients, 30 from PPG patients, and 35 from healthy individuals at Ankara Bilkent City Hospital Glaucoma Unit between January 2018 and September 2021. Eyes were categorized into control, PPG, and EG groups based on visual field (VF) classification.
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