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Comparison of the first episode with the first recurrent episode of takotsubo syndrome in 128 patients from the world literature: Pathophysiologic connotations.
Int J Cardiol
July 2020
Icahn School of Medicine at Mount Sinai, New York, NY, United States of America; Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, United States of America. Electronic address:
Background: The pathophysiology of takotsubo syndrome (TTS) and its recurrence (REC-TTS) is still elusive. Various ventriculographic "ballooning" patterns in response to a variety of triggers are observed in patients with REC-TTS. Although patients with and without REC-TTS have been previously compared, no comparison of patients' 1st TTS episode (1stTTS) with the 1st REC-TTS episode (1stREC-TTS) has been attempted.
View Article and Find Full Text PDFSpontaneous coronary artery dissection and its association with takotsubo syndrome: Novel insights from a tertiary center registry.
Catheter Cardiovasc Interv
February 2020
Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
Background: Spontaneous coronary artery dissection (SCAD) is a relatively rare cause of acute coronary syndrome historically thought to primarily affect young, healthy women. The lack of multicenter collaborative research efforts has made it challenging to identify the precise etiology and pathological mechanisms underlying SCAD. However, there are many similarities in the patient demographics, clinical presentations, and predisposing stressors between SCAD and takotsubo syndrome (TTS).
View Article and Find Full Text PDFGiant left ventricular thrombus formation associated with heparin-induced thrombocytopenia.
Ann Thorac Surg
December 2014
Department of Cardiovascular Surgery, University Hospital of Saint-Etienne, Saint-Etienne, France.
A 33-year-old man underwent urgent coronary artery de-obstruction for acute thrombotic occlusion of the left descending coronary artery. After 10 days of antiplatelet and heparin therapy, ventriculographic and echocardiographic control revealed a giant thrombus in the left ventricle, an ejection fraction of 40%, and severe mitral regurgitation. Heparin-induced thrombocytopenia was diagnosed.
View Article and Find Full Text PDFPheochromocytoma presenting as takotsubo-like cardiomyopathy following delivery.
Endocr Pract
December 2014
Department of Hypertension, Institute of Cardiology, Warsaw, Poland.
Objective: Diagnosis of pheochromocytoma during pregnancy can be difficult, and the tumor carries an unfavorable prognosis if not diagnosed and treated in a timely manner.
Methods: To present a case of Takotsubo-like cardiomyopathy characterized by transient left ventricular apical ballooning due to pheochromocytoma following delivery.
Results: A few hours after Caesarean section, a 32-year-old Caucasian female presented with pulmonary edema followed by cardiac arrest with echocardiographic and ventriculographic evidence of reversible acute myocardial failure characteristic of Takotsubo-like cardiomyopathy.
Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.
Circ Res
April 2014
From The Interdisciplinary Stem Cell Institute (V.Y.S., J.P.Z., V.K., N.M., D.L.D.V., K.S., I.H.S., S.N.T., A.R.W., C.S., J.D.S., I.K.M., J.M.H., A.W.H.), Departments of Medicine (J.P.Z., K.H.N., I.H.S., M.M., B.T., M.T., J.M.H., A.W.H.), and Radiology (E.G., J.E.F.), University of Miami Miller School of Medicine, FL; Cardiovascular Division, The Johns Hopkins University School of Medicine, Baltimore, MD (G.G., E.B., P.V.J., J.B., A.C.L., R.T.G.); Division of Cell Therapy, EMMES Corporation, Rockville, MD (A.M.M.); and Biocardia Inc, San Carlos, CA (P.A.). I.K.M is currently affiliated with the Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX. J.P.Z. is currently affiliated with Jackson South Community Hospital, Miami, FL. M.T. is currently affiliated with Rush University Medical Center, Chicago, IL.
Rationale: Transendocardial stem cell injection (TESI) with mesenchymal stem cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of the injection site remains unknown.
Objective: To address whether TESI exerts its effects at the site of injection only or also in remote areas, we hypothesized that segmental myocardial scar and segmental ejection fraction improve to a greater extent in injected than in noninjected segments.
Methods And Results: Biplane ventriculographic and endocardial tracings were recorded.
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