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Personalized Antenatal Corticosteroid Therapy and Central Nervous System Development: Reflections on the Gold Standard of Fetomaternal Therapy.
Diseases
December 2024
Department of Obstetrics and Gynecology and CERICSAL (Centro di Ricerca Clinico SALentino), "Veris delli Ponti Hospital", Via Giuseppina Delli Ponti, 73020 Scorrano, Lecce, Italy.
Background: The term "fetal programming" refers to the effects of endogenous and exogenous corticosteroids, whether received from the mother or the fetus, on brain development and the hypothalamic-pituitary-adrenal axis reset. The authors of this narrative review examine the WHO's guidelines for prenatal corticosteroids in pregnant women who are at high risk of premature delivery. These guidelines are regarded as the best available for preventing late-life problems resulting from preterm.
View Article and Find Full Text PDFGulf war illness is a chronic multisymptom disorder that affects as many as many as 25-35% of the military personnel who were sent to the Persian Gulf war in 1991. The illness has many debilitating symptoms, including cognitive problems, gastrointestinal symptoms, and musculoskeletal pain. Those so afflicted have been sick for more than 30 years and, therefore, it has become imperative to understand the etiology and then produce treatments to ease the symptoms.
View Article and Find Full Text PDFBurning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective.
Oral Dis
December 2024
Department of Preventive Medicine, Public Health and History of Science, Complutense University of Madrid, Madrid, Spain.
Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS).
Subjects And Methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).
Results: The structure of the associative pathways with the BMS was revealed.
Topical dexamethasone decelerates epithelial migration on the canine tympanic membrane.
Vet Dermatol
December 2024
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Background: Epithelial migration (EM) is integral to normal ear structure and function. Glucocorticoids are considered the first-line therapy for various external ear disorders; however, their effects on EM on the tympanic membrane (TM) and the external auditory canal (EAC) are understudied.
Hypothesis/objectives: To test the hypothesis that topical dexamethasone decelerates EM on the TM, this study aimed to evaluate the effects of topical dexamethasone on EM on the TMs of dogs.
Prioritising domains of glucocorticoid therapy to measure in trials: Results from a modified delphi exercise from the OMERACT glucocorticoid impact working group.
Semin Arthritis Rheum
December 2024
Division of Rheumatology, Weill Cornell Medicine, Hospital for Special Surgery, New York, United States. Electronic address:
Introduction: There is no consensus amongst patients and healthcare professionals about how to measure important adverse effects of glucocorticoids (GCs) that includes the patient's perspective. The OMERACT GC Impact working group sought to identify the domains of greatest importance to both patients and healthcare professionals for use in a proposed core outcome set.
Methods: Patients and healthcare professionals participated in a Delphi consensus exercise to rate the importance of previously identified candidate domains.
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