Anaphylaxis and anaphylactoid reactions are adverse immunologic responses that require early intervention to prevent life-threatening consequences. The initial symptoms, such as nasal congestion or pruritus, can quickly progress to cardiac collapse or asphyxiation. In this article, Drs Rusznak and Peebles discuss the mechanisms of these reactions, common causative agents, preventive strategies, recognition, and treatment.
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http://dx.doi.org/10.3810/pgm.2002.05.1207 | DOI Listing |
J Vasc Access
December 2024
Department of Catheter Clinic, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.
Aesthetic Plast Surg
December 2024
Multidisciplinary Department of Medical Surgery and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Background: Botulinum toxin type A (BTA) is a protein produced by Clostridium botulinum bacteria. It is the most widely used among botulinum toxin types, and it is recommended for the treatment of many clinical conditions, including muscle hyperactivity syndromes and for esthetic indications too. BTA is generally considered safe, and the most reported adverse events (AEs) include eyelids ptosis, immunogenicity, neuromuscular disorders and hypersensitivity reactions.
View Article and Find Full Text PDFChildren (Basel)
November 2024
Division of Gastroenterology, Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA.
Infliximab (IFX) is a recombinant DNA-derived chimeric IgG monoclonal antibody protein that inhibits tumor necrosis factor alpha (TNF-α). IFX, like other agents derived from foreign proteins, can cause infusion reactions both during and after the infusion. The incidence of infusion reactions ranges between 0% and 15% in pediatric patients.
View Article and Find Full Text PDFBMJ Case Rep
October 2024
Acute Medicine, University Hospitals Sussex NHS Foundation Trust, Chichester, West Sussex, UK.
A female in her 60s was admitted via the emergency department following a respiratory collapse at home. She was profoundly hypoxic and hypertensive. For 1 week prior, she had been self-administering subcutaneous (SC) low molecular weight heparin (LMWH) for a small postoperative pulmonary embolism (PE) and reported worsening, self-resolving episodes of breathlessness 1 hour post-injection.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. Electronic address:
Ethnopharmacological Relevance: Currently, adverse reactions limit the development of traditional Chinese medicine injections (TCMI), and severe anaphylactoid shock is one of the serious adverse reactions, which presents a significant challenge. The presence of abnormal inflammatory mediators before the administration of TCMI will most likely result in severe anaphylactoid reactions. Not only that, the lack of clinically relevant safety evaluations impedes the widespread use of TCMI, and there is an urgent need for studies to reveal the mechanisms of anaphylactoid shock caused by TCMI.
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