AI Article Synopsis
- The study evaluated the precision of magnetoencephalography (MEG) in measuring neuronal activity using N20m dipole moments from somatosensory evoked fields (SEFs) after median nerve stimulation.
- The assessment involved comparing results from neurologically stable patients over two weeks, establishing that a variation greater than 5.2 nAm is statistically significant.
- MEG identified more functional asymmetries than conventional cerebral blood flow (CBF) measurements, suggesting it could be a valuable clinical tool for quantifying cortical responses.
Article Abstract
To assess the accuracy of magnetoencephalography (MEG) as a tool for quantitative detection of neuronal activity, the dipole moment was estimated at N20m of somatosensory evoked fields (SEFs) produced by median nerve stimulation. Neurologically stable patients were examined twice within 2 weeks. Since the estimated moment values of the two examinations should be essentially the same, we assessed the margin of error for our measurement system. The results showed that a change of more than 5.2 nAm is statistically significant (p=0.05; n=91). The patients were classified as without or with functional asymmetries by measuring the conventional cerebral blood flow (CBF) with single photon emission CT (SPECT), and the dipole moment difference between hemispheres was measured. Hemispheric moment differences were statistically larger for the group with CBF laterality, indicating consistency between conventional CBF results and the moment measurements as a group. Moreover, MEG was able to detect more functional asymmetries than CBF study. The dipole moment provided a reliable quantitative index of cortical response to somatosensory stimulus, and the moment measurement thus holds promise as a clinical tool for direct quantification of cortical response.
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| http://dx.doi.org/10.1016/s0022-510x(02)00076-x | DOI Listing |
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