A series of N,N'-diphenyl and N-naphthyl-N'-phenyl guanidine derivatives was synthesized as potential N-methyl-D-aspartate (NMDA) receptor positron emission tomography (PET) ligands. The affinity of the different compounds was determined using in vitro receptor binding assays, and their log P values were estimated using HPLC analysis. The effect of N'-3 and N'-3,5 substitution on affinity and lipophilicity was examined. The K(i) values ranged from 1.87 to 839nM, while log P values between 1.22 and 2.88 were observed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(02)00235-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A data-driven approach to study temporal characteristics of COVID-19 infection and death Time Series for twelve countries across six continents.
BMC Med Res Methodol
January 2025
Systems Engineering & Operations Research, George Mason University, Fairfax, VA, 22030, USA.
Background: In this work, we implement a data-driven approach using an aggregation of several analytical methods to study the characteristics of COVID-19 daily infection and death time series and identify correlations and characteristic trends that can be corroborated to the time evolution of this disease. The datasets cover twelve distinct countries across six continents, from January 22, 2020 till March 1, 2022. This time span is partitioned into three windows: (1) pre-vaccine, (2) post-vaccine and pre-omicron (BA.
View Article and Find Full Text PDFModeling, evaluation and metrics performance of the SyncLMKD in distributed kinematics variations.
Sci Rep
January 2025
Graduate Program in Electrical and Computer Engineering, Universidade Tecnológica Federal do Paraná (UTFPR), Curitiba, 80230-901, Brazil.
Modeling the Digital Twin (DT) is an important resource for accurately representing the physical entity, enabling it to deliver functional services, meet application requirements, and address the disturbances between the physical and digital realms. This article introduces the Log Mean Kinematics Difference Synchronization (SyncLMKD) to measure the kinematic variations distributed among Digital Twin elements to ensure symmetric values relative to a reference. The proposed method employs abductive reasoning and draws inspiration from the Log Mean Temperature Difference (LMTD).
View Article and Find Full Text PDFAssociation of cardiometabolic index with all-cause and cardiovascular mortality among middle-aged and elderly populations.
Sci Rep
January 2025
Lianshui People's Hospital of Kangda college Affiliated to Nanjing Medical University, Hong Ri Dong Road, Lianshui County, 223499, Jiangsu, China.
The Cardiometabolic Index (CMI) is a well-recognized risk factor for a range of cardiovascular diseases and diabetes mellitus. However, the population-level characteristics of CMI and its potential association with mortality risk among individuals over 40 years of age have not been investigated. This study aims to assess the association between CMI and both all-cause and cardiovascular mortality among the middle-aged and elderly population.
View Article and Find Full Text PDFInvestigating the contributors to hit-and-run crashes using gradient boosting decision trees.
PLoS One
January 2025
School of Automobile and Traffic Engineering, Nanjing Forestry University, Nanjing, Jiangsu, China.
A classification prediction model is established based on a nonlinear method-Gradient Boosting Decision Tree (GBDT) to investigate the factors contributing to a perpetrator's escape behavior in hit-and-run crashes. Given the U.S.
View Article and Find Full Text PDFRecovery time and predictors of severe acute malnutrition in children aged 6-59 months via an outpatient therapeutic program in Borena zone: A prospective cohort study.
PLoS One
January 2025
Department of Reproductive Health, College of Medical and Health Sciences, Dilla University, Dilla, Ethiopia.
Background: Severe acute malnutrition (SAM) is a severe condition causing bilateral pitting edema or signs of wasting in children, with a high mortality risk. An outpatient therapeutic program is recommended for managing SAM children without complications, but there is limited information on recovery time and its determinants.
Objective: This study aims to assess the time to recovery and its predictors among children aged 6-59 months with SAM admitted to the Outpatient therapeutic program in the Borena zone, Oromia region, Southern Ethiopia in 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!