AI Article Synopsis
- A case of bloodstream infection caused by Candida haemulonii is described in a patient with a history of megaloblastic anemia, presenting with fever.
- The identification of the fungus was complicated due to misidentification by standard diagnostic systems (API 20C and VITEK).
- Susceptibility tests revealed that C. haemulonii showed resistance to amphotericin B and high MICs for fluconazole, indicating a need for further research on antifungal resistance mechanisms.
Article Abstract
A bloodstream infection due to Candida haemulonii afflicting a patient with fever and a medical history of megaloblastic anemia is reported. The clinical isolate was misidentified by the API 20C and VITEK identification systems. The results of susceptibility tests showed that the MIC of amphotericin B for C. haemulonii was 4 microg/ml. Additional susceptibility testing procedures based on the use of antibiotic medium 3 and Iso-Sensitest broth were performed, and killing curves were determined. Two collection strains of C. haemulonii were employed as controls. The three isolates exhibited resistance to amphotericin B in vitro regardless of the antifungal susceptibility testing method employed. In addition, the MICs of fluconazole for the three isolates were high. Further studies are needed in order to ascertain whether this species exhibits innate or acquired resistance to amphotericin B and other antifungal agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130759 | PMC |
| http://dx.doi.org/10.1128/JCM.40.6.2266-2269.2002 | DOI Listing |
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