A 3-step synthesis of 3-acetamido-6-arylpyridazines as potential NPY5 antagonists.
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http://dx.doi.org/10.1248/cpb.50.636 | DOI Listing |
Can J Kidney Health Dis
January 2025
Faculty of Health, College of Pharmacy, Dalhousie University, Halifax, NS, Canada.
Background: Diabetes is the leading cause of kidney disease and contributes to 38% of kidney failure requiring dialysis. A gap in detection and management of type 2 diabetes (T2D) in chronic kidney disease (CKD) exists in primary care. Community pharmacists are positioned to support those not able to access kidney care through traditional pathways.
View Article and Find Full Text PDFDalton Trans
January 2025
Department of Solid State Sciences, CoCooN research group, Ghent University, Krijgslaan 281 (S1), 9000 Gent, Belgium.
Phosphorous-containing materials are used in a wide array of fields, from energy conversion and storage to heterogeneous catalysis and biomaterials. Among these materials, organic-inorganic metal phosphonate solids and thin films present an interesting option, due to their remarkable thermal and chemical stability. Yet, the synthesis of phosphonate hybrids by vapour phase thin film deposition techniques remains largely unexplored.
View Article and Find Full Text PDFJBI Evid Synth
January 2025
LLUH Center for Evidence Synthesis, Loma Linda University Health, Loma Linda, California, USA.
Objective: The objective of the systematic review will be to evaluate the effect of paternity leave or fathers' parental leave on infant mortality rate, hospitalization, vaccination compliance, and breastfeeding duration.
Introduction: Current studies indicate that paternity leave positively affects infant health, but there is a significant lack of synthesized research on its impact on key infant health indicators. A systematic review of the existing evidence will help identify best practices and guide further research and policy development in this area.
J Org Chem
December 2024
Pfizer Oncology Medicinal Chemistry, San Diego, California 92121, United States.
A 3-step modular procedure combining carboxylic acids with acyl hydrazines provides access to medicinally relevant [1,2,4]-fused triazoles. Good to excellent yields are achieved with tolerance of aliphatic and aryl substituents as well as 5-, 6-, and 7-membered rings for the fused ring. Conditions that can avoid column chromatography and be applicable for both small scale discovery efforts as well as large scale development processes are demonstrated within.
View Article and Find Full Text PDFWaste Manag
December 2024
Energy, Mining and Environment Research Centre, National Research Council Canada, 6100 Royalmount Ave, Montreal, QC H4P 2R2, Canada.
The treatment of food waste by anaerobic digestion (AD) still faces several challenges. Fractionating the waste, with a screw press separator, into a liquid phase rich in soluble compounds and a solid fraction could contribute to reduce these challenges, provided that the solid fraction is valorized. To do so, hydrothermal carbonization was shown to be a promising option.
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