Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1006/viro.2002.1382 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Respiratory Virus-Induced PARP1 Alters DC Metabolism and Antiviral Immunity Inducing Pulmonary Immunopathology.
Viruses
June 2024
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Previous studies from our laboratory and others have established the dendritic cell (DC) as a key target of RSV that drives infection-induced pathology. Analysis of RSV-induced transcriptomic changes in RSV-infected DC revealed metabolic gene signatures suggestive of altered cellular metabolism. Reverse phase protein array (RPPA) data showed significantly increased PARP1 phosphorylation in RSV-infected DC.
View Article and Find Full Text PDFAnti-inflammatory effects of curcumin-loaded niosomes on respiratory syncytial virus infection in a mice model.
J Med Microbiol
April 2022
Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran.
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in paediatrics. While antivirals are apparent candidates to treat RSV-induced diseases, they have not yet met expectations and have remained in infancy. There is growing evidence to suggest that modulating the exacerbated inflammation during RSV infection can improve disease outcome.
View Article and Find Full Text PDFNLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development.
Viruses
April 2021
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk of developing asthma later in life. Previously, our group has shown that RSV infection in mice and infants promotes IL-1β production.
View Article and Find Full Text PDFEarly IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS Pathog
September 2017
Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, South Kensington Campus, South Kensington, London, United Kingdom.
Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and adaptive immune responses. In humans with respiratory virus infections, such as Respiratory Syncytial Virus (RSV), elevated concentrations of IL-6 are associated with more severe disease. In contrast the polymorphisms in the Il6 promoter which favour lower IL-6 production are associated with increased risk of both RSV and Rhinovirus infections.
View Article and Find Full Text PDFNotch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection.
J Immunol
February 2017
Department of Pathology, University of Michigan, Ann Arbor, MI 48109;
Regulatory T (T) cells establish tolerance, prevent inflammation at mucosal surfaces, and regulate immunopathology during infectious responses. Recent studies have shown that Delta-like ligand 4 (Dll4) was upregulated on APC after respiratory syncytial virus (RSV) infection, and its inhibition leads to exaggerated immunopathology. In the present study, we outline the role of Dll4 in T cell differentiation, stability, and function in RSV infection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!