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Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration.
Chem Pharm Bull (Tokyo)
December 2024
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University.
Enteric-coated microcapsules can protect roxithromycin (ROX) from acid hydrolysis enhancing efficacy, solubility, and dissolution rate, representing a promising oral formulation for children and patients with swallowing difficulties. ROX-layered core particles were obtained with polyvinylpyrrolidone (PVP) K30 as the binder and Eudragit L30 D-55 as the coating material using the Wurster process in a fluidized bed processor. The enteric-coated microcapsules were characterized using powder X-ray diffraction, differential scanning calorimetry, and polarized optical microscopy.
View Article and Find Full Text PDFInvestigation of Silver- and Plant Extract-Infused Polymer Systems: Antioxidant Properties and Kinetic Release.
Int J Mol Sci
November 2024
Department of Material Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 31-864 Kraków, Poland.
This study evaluated the impact of silver particles, suspended in flower extract, on the physicochemical characteristics and release dynamics of antioxidant compounds in PVP (polyvinylpyrrolidone)-based hydrogel systems. The hydrogels were synthesized via photopolymerization with fixed amounts of crosslinker (PEGDA) and photoinitiator, while the concentration of the silver-infused extract was systematically varied. Key properties, including the density, porosity, surface roughness, swelling capacity, and water vapor transmission rate (WVTR), were quantitatively analyzed.
View Article and Find Full Text PDFHarnessing the Power of Zinc Oxide Nanoparticles for Accelerated Wound Healing and Antimicrobial Action.
Int J Nanomedicine
December 2024
School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka, India.
Introduction: Zinc oxide nanoparticles (ZnONPs) have been the subject of substantial research by virtue of their utility across extensive downstream applications. Moreover, the ZnONPs are inexpensive, reliable, and easy to produce. Green synthesis employing biological systems, particularly plant extracts, has arisen as a subject of study in nanotechnology and is gaining importance due to its multiple applications in biology, chemistry, physics, and medicine.
View Article and Find Full Text PDFA Novel Self-Assembled Paclitaxel Nanodispersion Facilitates Rapid In-Vitro/In-Vivo Dissociation and Protein Binding.
AAPS PharmSciTech
December 2024
Formulation Research and Development, Sun Pharmaceutical Industries Ltd. , Tandalja, Vadodara, Gujarat, 390020, India.
The study aims to prepare and characterize a novel paclitaxel (PtX) preconcentrate formulation using polymer and lipid excipients that forms nanodispersion upon dilution. The goal was to understand the mechanism of nanodispersion formation and its properties. The water-insoluble PtX was dissolved in organic solvents containing ethanol, polyethylene glycol (PEG400), povidone (PVP), caprylic acid (CA), and sodium cholesterol sulfate (CS).
View Article and Find Full Text PDFMechanistic characterization of fast dissolving PVP-I powder with multipolymer approaches and investigation on their molecular interaction.
Pharm Dev Technol
December 2024
Drug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand.
Povidone-iodine (PVP-I) is widely used as an antiseptic in medical applications. However, its effectiveness is limited by certain drawbacks, such as low solubility in water and high volatility. Therefore, a formulation of a stable solid PVP-I is desirable.
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