Opioids are a commonly abused class of drugs. OxyContin abuse, a long-acting oxycodone derivative, has been increasingly identified as a potent narcotic resulting in drug dependence, overdose and even death. Use during pregnancy may result in withdrawal symptoms in the neonate. However, detection of the drug and its metabolites needs special methods in order to initiate appropriate therapy.
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Enhancing Postoperative Analgesia After Cesarean Section: Insights Into Transversus Abdominis Plane Block, Intrathecal Opioids, and Other Analgesic Techniques.
Cureus
October 2024
Anesthesia, Faculty of Medicine, Minia University, Minia, EGY.
Article Synopsis
- A clinical study was conducted to assess different pain management strategies after cesarean sections (CS) using 300 participants divided into five groups based on their anesthesia methods and analgesic protocols.
- Results indicated that the group receiving intrathecal morphine (ITM) reported the best pain relief and function, followed closely by the group combining spinal anesthesia with fentanyl and a TAP block (ITF+TAP).
- The general anesthesia group experienced the worst pain and had the quickest request for additional analgesia, highlighting the effectiveness of multimodal analgesia in enhancing postoperative recovery.
The impact of more restrictive hydrocodone rescheduling on unintentional pediatric opioid exposures.
Pharmacoepidemiol Drug Saf
June 2024
Office of Pharmacovigilance and Epidemiology (OPE), Office of Surveillance and Epidemiology (OSE), Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), Silver Spring, Maryland, USA.
Article Synopsis
- The study aimed to evaluate the effects of rescheduling hydrocodone combination products (HCPs) from a less restrictive schedule III to a more restrictive schedule II on unintentional pediatric exposures in children aged 5 and under.
- Analysis of U.S. data showed that after the rescheduling in October 2014, there was a significant drop in pediatric emergency department visits and poison center cases related to hydrocodone, decreasing by over 50%, while oxycodone cases remained stable and codeine cases slightly increased.
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Breast milk oxycodone concentrations in mothers given oxycodone for post-Caesarean delivery pain management.
Br J Clin Pharmacol
April 2024
Department of Anesthesia and Intensive Care, Kuopio University Hospital, Kuopio, Finland.
Aims: Both effective analgesia and early breastfeeding play an important role in maternal and neonatal well-being after Caesarean delivery. We studied controlled-release oxycodone tablet treatment for postoperative pain management and determined the excretion of oxycodone into breast milk.
Methods: Controlled-release oxycodone/naloxone 10/5-mg tablets (n = 21) or controlled-release oxycodone 10-mg tablets (n = 22) were administered to mothers twice a day for the first 3 days after elective Caesarean delivery as a part of multimodal analgesia.
Effect of prenatal and early post-natal oxycodone exposure on the reinforcing and antinociceptive effects of oxycodone in adult C57BL/6 J mice.
Psychopharmacology (Berl)
February 2024
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA.
Unlabelled: Abuse of opioids (mu-opioid agonists such as oxycodone) among parents during the gestation and early post-natal period is a concern for the long-term health of the offspring, beyond potential neonatal withdrawal symptoms. However, there is only limited information on such effects.
Objectives: We examined how prenatal, and early-post natal oxycodone exposure affected opioid addiction behaviors.
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