A recent meeting brought together electron microscopists, crystallographers and modellers to consider the problems facing structural biologists who wish to understand large, subcellular machines, and how the methods should be extended to achieve this goal.
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Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma.
Acta Biomater
January 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Glioblastoma (GBM) persists as a highly fatal malignancy, with current clinical treatments showing minimal progress over years. Interstitial photodynamic therapy (iPDT) holds promise due to its minimally invasive nature and low toxicity but is impeded by poor photosensitizer penetration and inadequate GBM targeting. Here, we developed a biomimetic pure-drug nanomedicine (MM@CT), which co-assembles the photosensitizer chlorin e6 (Ce6) and the first-line chemotherapeutic drug (temozolomide, TMZ) for GBM, then camouflaged with macrophage membranes.
View Article and Find Full Text PDFStudy on the preparation and design of chenille/polyester integrated yarns and its acoustic properties.
Sci Rep
January 2025
Shanghai Frontiers Science Research Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China.
With the rapid development of industrialization and urbanization, the impact of noise on people's health has become an increasingly serious issue, but it is still a challenge for the reducing the noise due to its complex property. Textiles with many loose porous structures have gained much significant attentions, thus chenille yarns with plush fibers on the surface, and polyester monofilament were chosen to fabricate the integrated knitting yarns, and their fundamental and mechanical properties were fully evaluated. The results showed that the diameter and braiding angle of the blended yarns decreased with the increase of pitch, resulting in a linear correlation of R > 0.
View Article and Find Full Text PDFEngineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy.
Nat Commun
January 2025
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Hypoxic tumors present a significant challenge in cancer therapy due to their ability to adaptation in low-oxygen environments, which supports tumor survival and resistance to treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is a crucial mechanism that helps sustain cellular homeostasis in hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, that co-delivers hydroxychloroquine and a mitochondria-targeting photosensitizer, designed to induce cascaded oxidative stress by regulating mitophagy for the treatment of hypoxic tumors.
View Article and Find Full Text PDFRational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.
ACS Nano
January 2025
School of Medicine, Nankai University, Tianjin 300071, China.
Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.
View Article and Find Full Text PDFExtracellular Vesicles: Advanced Tools for Disease Diagnosis, Monitoring, and Therapies.
Int J Mol Sci
December 2024
Department of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Extracellular vesicles (EVs) are a heterogeneous group of membrane-encapsulated vesicles released by cells into the extracellular space. They play a crucial role in intercellular communication by transporting bioactive molecules such as proteins, lipids, and nucleic acids. EVs can be detected in body fluids, including blood plasma, urine, saliva, amniotic fluid, breast milk, and pleural ascites.
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